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APOE ɛ4, but not polygenic Alzheimer’s disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals

The hippocampus is affected early in Alzheimer’s disease (AD) and altered hippocampal functioning influences normal cognitive aging. Here, we used task-based functional MRI to assess if the APOE ɛ4 allele or a polygenic risk score (PRS) for AD was linked to longitudinal changes in memory-related hip...

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Detalles Bibliográficos
Autores principales:	Håglin, Sofia, Koch, Elise, Schäfer Hackenhaar, Fernanda, Nyberg, Lars, Kauppi, Karolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209089/ https://www.ncbi.nlm.nih.gov/pubmed/37225733 http://dx.doi.org/10.1038/s41598-023-35316-z

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