Cargando…

16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability

Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry strong genetic risk for autism, yet their neurobiological impact is poorly characterised, particularly at the integrated systems level. Here we show that mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Openshaw, Rebecca L., Thomson, David M., Bristow, Greg C., Mitchell, Emma J., Pratt, Judith A., Morris, Brian J., Dawson, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209099/ https://www.ncbi.nlm.nih.gov/pubmed/37225770 http://dx.doi.org/10.1038/s42003-023-04891-2

Ejemplares similares

Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions
por: Mitchell, Emma J., et al.
Publicado: (2020)

F41. SCHIZOPHRENIA-RELEVANT ALTERATIONS IN CEREBRAL METABOLISM, GLUTAMATE AND MONOAMINERGIC NEUROTRANSMITTER SYSTEM FUNCTION IN A MOUSE MODEL OF 16P11.2 DUPLICATION
por: Bristow, Greg, et al.
Publicado: (2018)

Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction
por: Thomson, David M, et al.
Publicado: (2021)

Sensory processing in 16p11.2 deletion and 16p11.2 duplication
por: Smith, Harriet, et al.
Publicado: (2022)

Reduced Fronto-Temporal and Limbic Connectivity in the 22q11.2 Deletion Syndrome: Vulnerability Markers for Developing Schizophrenia?
por: Ottet, Marie-Christine, et al.
Publicado: (2013)

M162. FRONTO-STRIATAL-THALAMIC CIRCUITRY ABNORMALITIES IN WHITE MATTER TRACTS IN INDIVIDUALS WITH 22Q11.2 DELETION SYNDROME
por: Heller, Carina, et al.
Publicado: (2020)

Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses
por: Connacher, Robert, et al.
Publicado: (2022)

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses
por: Connacher, Robert, et al.
Publicado: (2022)

Abnormal auditory and language pathways in children with 16p11.2 deletion
por: Berman, Jeffrey I., et al.
Publicado: (2015)

Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions
por: Demopoulos, Carly, et al.
Publicado: (2018)

Correction: Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids
por: Fetit, Rana, et al.
Publicado: (2023)

Characterizing cognitive control abilities in children with 16p11.2 deletion using adaptive ‘video game' technology: a pilot study
por: Anguera, J A, et al.
Publicado: (2016)

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline
por: Openshaw, R.L., et al.
Publicado: (2016)

Association of fronto-temporal function with cognitive ability in schizophrenia
por: Pu, Shenghong, et al.
Publicado: (2017)

Fronto-parietal involvement in chronic stroke motor performance when corticospinal tract integrity is compromised
por: Hordacre, Brenton, et al.
Publicado: (2021)

Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity
por: Perrone, Laura, et al.
Publicado: (2010)

16p11.2 deletion in patients with paroxysmal kinesigenic dyskinesia but without intellectual disability
por: Li, Wen, et al.
Publicado: (2018)

Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome
por: Stoddard, Joel, et al.
Publicado: (2010)

Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications
por: Hudac, Caitlin M., et al.
Publicado: (2015)

Deletion and duplication of 16p11.2 are associated with opposing effects on visual evoked potential amplitude
por: LeBlanc, Jocelyn J., et al.
Publicado: (2016)

Clinical Characteristics of Seizures and Epilepsy in Individuals With Recurrent Deletions and Duplications in the 16p11.2 Region
por: Moufawad El Achkar, Christelle, et al.
Publicado: (2022)

Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome
por: Gundersen, Brigitta B., et al.
Publicado: (2023)

BDNF and JNK Signaling Modulate Cortical Interneuron and Perineuronal Net Development: Implications for Schizophrenia-Linked 16p11.2 Duplication Syndrome
por: Willis, Ashleigh, et al.
Publicado: (2020)

Adult Height, 22q11.2 Deletion Extent, and Short Stature in 22q11.2 Deletion Syndrome
por: Heung, Tracy, et al.
Publicado: (2022)

The clinical presentation of attention deficit‐hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome
por: Niarchou, Maria, et al.
Publicado: (2015)

Trait anger modulates neural activity in the fronto-parietal attention network
por: Alia-Klein, Nelly, et al.
Publicado: (2018)

Compromises with Nature
por: Pratt, Ben. H.
Publicado: (1876)

A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders
por: Zufferey, Flore, et al.
Publicado: (2012)

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks
por: Yang, Mu, et al.
Publicado: (2015)

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes
por: Arbogast, Thomas, et al.
Publicado: (2016)

Male‐specific alterations in structure of isolation call sequences of mouse pups with 16p11.2 deletion
por: Agarwalla, Swapna, et al.
Publicado: (2020)

Hyperinsulinism in a patient with a Zellweger Spectrum Disorder and a 16p11.2 deletion syndrome
por: Hoytema van Konijnenburg, Eva M.M., et al.
Publicado: (2020)

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
por: Abel, Ted, et al.
Publicado: (2023)

Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study
por: Vingerhoets, Claudia, et al.
Publicado: (2020)

Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control
por: Maurer, Gianna W., et al.
Publicado: (2020)

Deletion of FGF9 in GABAergic neurons causes epilepsy
por: Guo, Moran, et al.
Publicado: (2021)

Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome
por: Niarchou, Maria, et al.
Publicado: (2019)

Expression of Genes in the 16p11.2 Locus during Development of the Human Fetal Cerebral Cortex
por: Morson, Sarah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_msqbg7qhiuos87ko26es7e80g8