Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD-proteinopathy. We identified mitochondrial DNA (mtDNA) as...

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Detalles Bibliográficos
Autores principales: Van Acker, Zoë P., Perdok, Anika, Hellemans, Ruben, North, Katherine, Vorsters, Inge, Cappel, Cedric, Dehairs, Jonas, Swinnen, Johannes V., Sannerud, Ragna, Bretou, Marine, Damme, Markus, Annaert, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209153/
https://www.ncbi.nlm.nih.gov/pubmed/37225734
http://dx.doi.org/10.1038/s41467-023-38501-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209153/
https://www.ncbi.nlm.nih.gov/pubmed/37225734
http://dx.doi.org/10.1038/s41467-023-38501-w

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