Cargando…

Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD-proteinopathy. We identified mitochondrial DNA (mtDNA) as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van Acker, Zoë P., Perdok, Anika, Hellemans, Ruben, North, Katherine, Vorsters, Inge, Cappel, Cedric, Dehairs, Jonas, Swinnen, Johannes V., Sannerud, Ragna, Bretou, Marine, Damme, Markus, Annaert, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209153/ https://www.ncbi.nlm.nih.gov/pubmed/37225734 http://dx.doi.org/10.1038/s41467-023-38501-w

Ejemplares similares

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
por: Van Acker, Zoë P., et al.
Publicado: (2019)

ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation
por: Raemaekers, Tim, et al.
Publicado: (2012)

Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane
por: Paparelli, Laura, et al.
Publicado: (2016)

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum
por: Wouters, Rosanne, et al.
Publicado: (2021)

Sorting out the cell biology of Alzheimer’s disease: focus on BACE1 and APP
por: Annaert, Wim
Publicado: (2012)

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system
por: Hamouda, Norin Nabil, et al.
Publicado: (2020)

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface
por: Escamilla-Ayala, Abril Angélica, et al.
Publicado: (2020)

Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3
por: Gijs, Hannah Laura, et al.
Publicado: (2015)

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency
por: Tharkeshwar, Arun Kumar, et al.
Publicado: (2017)

Quantification and characterization of the 5′ exonuclease activity of the lysosomal nuclease PLD3 by a novel cell-based assay
por: Cappel, Cedric, et al.
Publicado: (2020)

CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing
por: Dehairs, Jonas, et al.
Publicado: (2016)

The use of urine in the follow-up of HPV vaccine trials
por: Vorsters, Alex, et al.
Publicado: (2015)

Hepatitis B Vaccines
por: Pattyn, Jade, et al.
Publicado: (2021)

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
por: Guix, Francesc X., et al.
Publicado: (2017)

The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin
por: Li, Hai-Sheng, et al.
Publicado: (2003)

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites
por: Vrijsen, Stephanie, et al.
Publicado: (2022)

Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine
por: Pattyn, Jade, et al.
Publicado: (2020)

Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?
por: Peric, Aleksandar, et al.
Publicado: (2015)

The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication
por: Yang, Xiaojuan, et al.
Publicado: (2021)

Burden and prevention of viral hepatitis in the Arctic region, Copenhagen, Denmark, 22–23 March 2012
por: FitzSimons, David, et al.
Publicado: (2013)

Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels
por: Van Acker, Zoë P., et al.
Publicado: (2017)

Infection and vaccine-induced HPV-specific antibodies in cervicovaginal secretions. A review of the literature
por: Pattyn, Jade, et al.
Publicado: (2019)

Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples
por: Van Keer, Severien, et al.
Publicado: (2018)

Where Notch and WNT Signaling Meet: The Presenilin Hub
por: De Strooper, Bart, et al.
Publicado: (2001)

Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer’s disease
por: Jurisch-Yaksi, Nathalie, et al.
Publicado: (2013)

A Single Nucleotide Polymorphism in the Phospholipase D1 Gene is Associated with Risk of Non-Small Cell Lung Cancer
por: Ahn, Myung-Ju, et al.
Publicado: (2012)

AMPylation profiling during neuronal differentiation reveals extensive variation on lysosomal proteins
por: Becker, Tobias, et al.
Publicado: (2021)

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System
por: Fikatas, Antonios, et al.
Publicado: (2021)

Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
por: Fu, Guoping, et al.
Publicado: (2010)

Phospholipases A in Trypanosomatids
por: Belaunzarán, María Laura, et al.
Publicado: (2011)

Phospholipases A(1)
por: Richmond, Gregory S., et al.
Publicado: (2011)

p53 attenuates AKT signaling by modulating membrane phospholipid composition
por: Rueda-Rincon, Natalia, et al.
Publicado: (2015)

Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition
por: Tharkeshwar, Arun Kumar, et al.
Publicado: (2020)

Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
por: Oh-hora, Masatsugu, et al.
Publicado: (2003)

PSMA-PET-CT zum primären Staging von Patienten mit fortgeschrittenem Prostatakarzinom
por: Cappel, Cedric Curt, et al.
Publicado: (2021)

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes
por: Griveau, Audrey, et al.
Publicado: (2018)

Acceptability and efficacy of the Zemedy app versus a relaxation training and meditation app for IBS: protocol for a randomised controlled trial
por: Hunt, Melissa G, et al.
Publicado: (2022)

Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis
por: Juszczak, Florian, et al.
Publicado: (2023)

The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma
por: Faict, Sylvia, et al.
Publicado: (2019)

A Review of Persuasive Principles in Mobile Apps for Chronic Arthritis Patients: Opportunities for Improvement
por: Geuens, Jonas, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8u7nds87cp9qfee50ql2uat9hg