Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (CTAD)]. Although the roles of HIF-1α NTAD in kidney diseases have been recognized, the exac...

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Detalles Bibliográficos
Autores principales: Li, Zuo-Lin, Ding, Lin, Ma, Rui-Xia, Zhang, Yue, Zhang, Yi-Lin, Ni, Wei-Jie, Tang, Tao-Tao, Wang, Gui-Hua, Wang, Bin, Lv, Lin-Li, Wu, Qiu-Li, Wen, Yi, Liu, Bi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209155/
https://www.ncbi.nlm.nih.gov/pubmed/37225700
http://dx.doi.org/10.1038/s41419-023-05854-5

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