P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma

Glioblastomas are highly aggressive and deadly brain tumours, with a median survival time of 14–18 months post-diagnosis. Current treatment modalities are limited and only modestly increase survival time. Effective therapeutic alternatives are urgently needed. The purinergic P2X7 receptor (P2X7R) is...

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Detalles Bibliográficos
Autores principales: Kan, Liyen K., Drill, Matthew, Jayakrishnan, Padmakrishnan C., Sequeira, Richard P., Galea, Emily, Todaro, Marian, Sanfilippo, Paul G., Hunn, Martin, Williams, David A., O’Brien, Terence J., Drummond, Katharine J., Monif, Mastura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209214/
https://www.ncbi.nlm.nih.gov/pubmed/37225786
http://dx.doi.org/10.1038/s41598-023-35712-5

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