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Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data
BACKGROUND: In India, facility-based surveillance for congenital rubella syndrome (CRS) was initiated in 2016 to estimate the burden and monitor the progress made in rubella control. We analyzed the surveillance data for 2016–2021 from 14 sentinel sites to describe the epidemiology of CRS. METHOD: W...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209330/ https://www.ncbi.nlm.nih.gov/pubmed/37251844 http://dx.doi.org/10.1016/j.heliyon.2023.e15965 |
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author | Shanmugasundaram, Devika Verma, Sanjay Singh, Kuldeep Dwibedi, Bhagirathi Awasthi, Shally Mahantesh, S. Singh, Himabindu Santhanam, Sridhar Mondal, Nivedita S, Geetha Sreenivasan, Priya Malik, Shikha Jain, Manish Viswanathan, Rajlakshmi Tripathi, Shalini Patel, Bhupeshwari Sapkal, Gajanan Sabarinathan, R. Singh, Mini P. Ratho, R.K. Nag, Vijaylakshmi Gadepalli, Ravishekhar Som, Tapas Kumar Mishra, Baijayantimala Jain, Amita Ashok, M. Madhuri, Devara Sudha Rani, V Sudha Abraham, Asha Mary John, Deepa Dhodapkar, Rahul Syed Ali, A. Biswas, Debasis Pratyeke, Deepashri Bavdekar, Ashish Prakash, Jayant Singh, Varsha Prasad, Nidhi Ray, Jaydeb Majumdar, Agniva Dutta, Shanta Gupta, Nivedita Murhekar, Manoj Sharma, Akhil Ghosh, Aniruddha Alexander, Arun Baranwal, Arun Anantharaj, Avinash Bethou, Adhisivam Shekhawat, Dolat S. Kiruthika, G. Ram, Jagat Gupta, Madhu Gowda, Mamatha Rohit, Manoj K Dash, Nabaneeta Sankhyan, Naveen Kaushal, Nidhi Shivanna, Niranjan Hunasanahalli Kasturi, Nirupama Kumar, P. Prem Gupta, Parul Chawla Gunasekaran, Pradeep Kumar Singh, Pratibha Kumar, Praveen Munjal, Sanjay Kumar Agarwal, Siddharth Manasa, Suhani Shukla, Suruchi Nehra, Urvashi Verghese, Valsan P Vyas, Varuna Gupta, Vikas |
author_facet | Shanmugasundaram, Devika Verma, Sanjay Singh, Kuldeep Dwibedi, Bhagirathi Awasthi, Shally Mahantesh, S. Singh, Himabindu Santhanam, Sridhar Mondal, Nivedita S, Geetha Sreenivasan, Priya Malik, Shikha Jain, Manish Viswanathan, Rajlakshmi Tripathi, Shalini Patel, Bhupeshwari Sapkal, Gajanan Sabarinathan, R. Singh, Mini P. Ratho, R.K. Nag, Vijaylakshmi Gadepalli, Ravishekhar Som, Tapas Kumar Mishra, Baijayantimala Jain, Amita Ashok, M. Madhuri, Devara Sudha Rani, V Sudha Abraham, Asha Mary John, Deepa Dhodapkar, Rahul Syed Ali, A. Biswas, Debasis Pratyeke, Deepashri Bavdekar, Ashish Prakash, Jayant Singh, Varsha Prasad, Nidhi Ray, Jaydeb Majumdar, Agniva Dutta, Shanta Gupta, Nivedita Murhekar, Manoj Sharma, Akhil Ghosh, Aniruddha Alexander, Arun Baranwal, Arun Anantharaj, Avinash Bethou, Adhisivam Shekhawat, Dolat S. Kiruthika, G. Ram, Jagat Gupta, Madhu Gowda, Mamatha Rohit, Manoj K Dash, Nabaneeta Sankhyan, Naveen Kaushal, Nidhi Shivanna, Niranjan Hunasanahalli Kasturi, Nirupama Kumar, P. Prem Gupta, Parul Chawla Gunasekaran, Pradeep Kumar Singh, Pratibha Kumar, Praveen Munjal, Sanjay Kumar Agarwal, Siddharth Manasa, Suhani Shukla, Suruchi Nehra, Urvashi Verghese, Valsan P Vyas, Varuna Gupta, Vikas |
author_sort | Shanmugasundaram, Devika |
collection | PubMed |
description | BACKGROUND: In India, facility-based surveillance for congenital rubella syndrome (CRS) was initiated in 2016 to estimate the burden and monitor the progress made in rubella control. We analyzed the surveillance data for 2016–2021 from 14 sentinel sites to describe the epidemiology of CRS. METHOD: We analyzed the surveillance data to describe the distribution of suspected and laboratory confirmed CRS patients by time, place and person characteristics. We compared clinical signs of laboratory confirmed CRS and discarded case-patients to find independent predictors of CRS using logistic regression analysis and developed a risk prediction model. RESULTS: During 2016–21, surveillance sites enrolled 3940 suspected CRS case-patients (Age 3.5 months, SD: 3.5). About one-fifth (n = 813, 20.6%) were enrolled during newborn examination. Of the suspected CRS patients, 493 (12.5%) had laboratory evidence of rubella infection. The proportion of laboratory confirmed CRS cases declined from 26% in 2017 to 8.7% in 2021. Laboratory confirmed patients had higher odds of having hearing impairment (Odds ratio [OR] = 9.5, 95% confidence interval [CI]: 5.6–16.2), cataract (OR = 7.8, 95% CI: 5.4–11.2), pigmentary retinopathy (OR = 6.7, 95 CI: 3.3–13.6), structural heart defect with hearing impairment (OR = 3.8, 95% CI: 1.2–12.2) and glaucoma (OR = 3.1, 95% CI: 1.2–8.1). Nomogram, along with a web version, was developed. CONCLUSIONS: Rubella continues to be a significant public health issue in India. The declining trend of test positivity among suspected CRS case-patients needs to be monitored through continued surveillance in these sentinel sites. |
format | Online Article Text |
id | pubmed-10209330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102093302023-05-26 Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data Shanmugasundaram, Devika Verma, Sanjay Singh, Kuldeep Dwibedi, Bhagirathi Awasthi, Shally Mahantesh, S. Singh, Himabindu Santhanam, Sridhar Mondal, Nivedita S, Geetha Sreenivasan, Priya Malik, Shikha Jain, Manish Viswanathan, Rajlakshmi Tripathi, Shalini Patel, Bhupeshwari Sapkal, Gajanan Sabarinathan, R. Singh, Mini P. Ratho, R.K. Nag, Vijaylakshmi Gadepalli, Ravishekhar Som, Tapas Kumar Mishra, Baijayantimala Jain, Amita Ashok, M. Madhuri, Devara Sudha Rani, V Sudha Abraham, Asha Mary John, Deepa Dhodapkar, Rahul Syed Ali, A. Biswas, Debasis Pratyeke, Deepashri Bavdekar, Ashish Prakash, Jayant Singh, Varsha Prasad, Nidhi Ray, Jaydeb Majumdar, Agniva Dutta, Shanta Gupta, Nivedita Murhekar, Manoj Sharma, Akhil Ghosh, Aniruddha Alexander, Arun Baranwal, Arun Anantharaj, Avinash Bethou, Adhisivam Shekhawat, Dolat S. Kiruthika, G. Ram, Jagat Gupta, Madhu Gowda, Mamatha Rohit, Manoj K Dash, Nabaneeta Sankhyan, Naveen Kaushal, Nidhi Shivanna, Niranjan Hunasanahalli Kasturi, Nirupama Kumar, P. Prem Gupta, Parul Chawla Gunasekaran, Pradeep Kumar Singh, Pratibha Kumar, Praveen Munjal, Sanjay Kumar Agarwal, Siddharth Manasa, Suhani Shukla, Suruchi Nehra, Urvashi Verghese, Valsan P Vyas, Varuna Gupta, Vikas Heliyon Research Article BACKGROUND: In India, facility-based surveillance for congenital rubella syndrome (CRS) was initiated in 2016 to estimate the burden and monitor the progress made in rubella control. We analyzed the surveillance data for 2016–2021 from 14 sentinel sites to describe the epidemiology of CRS. METHOD: We analyzed the surveillance data to describe the distribution of suspected and laboratory confirmed CRS patients by time, place and person characteristics. We compared clinical signs of laboratory confirmed CRS and discarded case-patients to find independent predictors of CRS using logistic regression analysis and developed a risk prediction model. RESULTS: During 2016–21, surveillance sites enrolled 3940 suspected CRS case-patients (Age 3.5 months, SD: 3.5). About one-fifth (n = 813, 20.6%) were enrolled during newborn examination. Of the suspected CRS patients, 493 (12.5%) had laboratory evidence of rubella infection. The proportion of laboratory confirmed CRS cases declined from 26% in 2017 to 8.7% in 2021. Laboratory confirmed patients had higher odds of having hearing impairment (Odds ratio [OR] = 9.5, 95% confidence interval [CI]: 5.6–16.2), cataract (OR = 7.8, 95% CI: 5.4–11.2), pigmentary retinopathy (OR = 6.7, 95 CI: 3.3–13.6), structural heart defect with hearing impairment (OR = 3.8, 95% CI: 1.2–12.2) and glaucoma (OR = 3.1, 95% CI: 1.2–8.1). Nomogram, along with a web version, was developed. CONCLUSIONS: Rubella continues to be a significant public health issue in India. The declining trend of test positivity among suspected CRS case-patients needs to be monitored through continued surveillance in these sentinel sites. Elsevier 2023-05-09 /pmc/articles/PMC10209330/ /pubmed/37251844 http://dx.doi.org/10.1016/j.heliyon.2023.e15965 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Shanmugasundaram, Devika Verma, Sanjay Singh, Kuldeep Dwibedi, Bhagirathi Awasthi, Shally Mahantesh, S. Singh, Himabindu Santhanam, Sridhar Mondal, Nivedita S, Geetha Sreenivasan, Priya Malik, Shikha Jain, Manish Viswanathan, Rajlakshmi Tripathi, Shalini Patel, Bhupeshwari Sapkal, Gajanan Sabarinathan, R. Singh, Mini P. Ratho, R.K. Nag, Vijaylakshmi Gadepalli, Ravishekhar Som, Tapas Kumar Mishra, Baijayantimala Jain, Amita Ashok, M. Madhuri, Devara Sudha Rani, V Sudha Abraham, Asha Mary John, Deepa Dhodapkar, Rahul Syed Ali, A. Biswas, Debasis Pratyeke, Deepashri Bavdekar, Ashish Prakash, Jayant Singh, Varsha Prasad, Nidhi Ray, Jaydeb Majumdar, Agniva Dutta, Shanta Gupta, Nivedita Murhekar, Manoj Sharma, Akhil Ghosh, Aniruddha Alexander, Arun Baranwal, Arun Anantharaj, Avinash Bethou, Adhisivam Shekhawat, Dolat S. Kiruthika, G. Ram, Jagat Gupta, Madhu Gowda, Mamatha Rohit, Manoj K Dash, Nabaneeta Sankhyan, Naveen Kaushal, Nidhi Shivanna, Niranjan Hunasanahalli Kasturi, Nirupama Kumar, P. Prem Gupta, Parul Chawla Gunasekaran, Pradeep Kumar Singh, Pratibha Kumar, Praveen Munjal, Sanjay Kumar Agarwal, Siddharth Manasa, Suhani Shukla, Suruchi Nehra, Urvashi Verghese, Valsan P Vyas, Varuna Gupta, Vikas Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title | Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title_full | Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title_fullStr | Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title_full_unstemmed | Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title_short | Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data |
title_sort | congenital rubella syndrome surveillance in india, 2016–21: analysis of five years surveillance data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209330/ https://www.ncbi.nlm.nih.gov/pubmed/37251844 http://dx.doi.org/10.1016/j.heliyon.2023.e15965 |
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