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A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response

A major theme of host against invading pathogens lies in multiple regulatory nodes that ensure sufficient signals for protection while avoiding excessive signals toward over-inflammation. The TLR4/MD-2/CD14 complex receptor-mediated response to bacterial lipopolysaccharide (LPS) represents a paradig...

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Detalles Bibliográficos
Autores principales: Zhu, Xinyu, Zhang, Linxia, Feng, Daobin, Jiang, Lang, Sun, Peng, Zhao, Chen, Zhang, Xiaoyan, Xu, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209397/
https://www.ncbi.nlm.nih.gov/pubmed/37250795
http://dx.doi.org/10.1016/j.isci.2023.106808