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Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls

Cryptorchid bulls have low economic value owing to the effects of masculinization. Moreover, surgical removal of an ectopic testis is difficult in certain clinical cases. Recently, immunocastration has garnered popularity as a nonsurgical castration method in pig farming; however, the effects of imm...

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Autores principales: GOTO, Akira, YOSHIDA, Nanako, NAKADA, Ken, INOUE, Yoichi, HISAEDA, Keiichi, INABA, Toshio, DOMOTO, Nanami, ISHIGURO, Yuki, ITOH, Megumi, TAKAHASHI, Eiji, SASAKI, Motoki, MATSUI, Motozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209463/
https://www.ncbi.nlm.nih.gov/pubmed/36927961
http://dx.doi.org/10.1292/jvms.22-0571
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author GOTO, Akira
YOSHIDA, Nanako
NAKADA, Ken
INOUE, Yoichi
HISAEDA, Keiichi
INABA, Toshio
DOMOTO, Nanami
ISHIGURO, Yuki
ITOH, Megumi
TAKAHASHI, Eiji
SASAKI, Motoki
MATSUI, Motozumi
author_facet GOTO, Akira
YOSHIDA, Nanako
NAKADA, Ken
INOUE, Yoichi
HISAEDA, Keiichi
INABA, Toshio
DOMOTO, Nanami
ISHIGURO, Yuki
ITOH, Megumi
TAKAHASHI, Eiji
SASAKI, Motoki
MATSUI, Motozumi
author_sort GOTO, Akira
collection PubMed
description Cryptorchid bulls have low economic value owing to the effects of masculinization. Moreover, surgical removal of an ectopic testis is difficult in certain clinical cases. Recently, immunocastration has garnered popularity as a nonsurgical castration method in pig farming; however, the effects of immunocastration on cryptorchid bulls are yet to be yet. Herein, we investigated endocrine changes due to immunocastration in cryptorchid bulls and studied its effectiveness. This study included 13 Holstein bulls diagnosed with cryptorchidism and classified into two groups based on pubertal period: <8 months of age (pregroup) and ≥8 months of age (postgroup). Antigonadotropin-releasing hormone (GnRH) vaccine was used for immunocastration, and two vaccine doses were administered. Blood testosterone and anti-Müllerian hormone (AMH) levels were measured and analyzed for endocrine evaluation. The testosterone levels significantly decreased following the start of immunocastration in both groups, thereby confirming the efficacy of antiGnRH vaccination in cryptorchid bulls. The AMH levels significantly increased in the pregroup with two antiGnRH vaccination, suggesting a compensatory response via the neutralization of GnRH antibodies. The AMH levels did not significantly change in the postgroup, indicating the partial suppression of AMH secretion in Sertoli cells during sexual maturation and failure of Sertoli cell maturation. Thus, we successfully restrained the serum testosterone levels in cryptorchid bulls using antiGnRH vaccine. The testosterone levels are a useful indicator of the immunocastration effect on cryptorchid bulls. Hereafter, a vaccine program that can sustain the castration effect on cryptorchid bulls is necessary.
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spelling pubmed-102094632023-05-26 Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls GOTO, Akira YOSHIDA, Nanako NAKADA, Ken INOUE, Yoichi HISAEDA, Keiichi INABA, Toshio DOMOTO, Nanami ISHIGURO, Yuki ITOH, Megumi TAKAHASHI, Eiji SASAKI, Motoki MATSUI, Motozumi J Vet Med Sci Theriogenology Cryptorchid bulls have low economic value owing to the effects of masculinization. Moreover, surgical removal of an ectopic testis is difficult in certain clinical cases. Recently, immunocastration has garnered popularity as a nonsurgical castration method in pig farming; however, the effects of immunocastration on cryptorchid bulls are yet to be yet. Herein, we investigated endocrine changes due to immunocastration in cryptorchid bulls and studied its effectiveness. This study included 13 Holstein bulls diagnosed with cryptorchidism and classified into two groups based on pubertal period: <8 months of age (pregroup) and ≥8 months of age (postgroup). Antigonadotropin-releasing hormone (GnRH) vaccine was used for immunocastration, and two vaccine doses were administered. Blood testosterone and anti-Müllerian hormone (AMH) levels were measured and analyzed for endocrine evaluation. The testosterone levels significantly decreased following the start of immunocastration in both groups, thereby confirming the efficacy of antiGnRH vaccination in cryptorchid bulls. The AMH levels significantly increased in the pregroup with two antiGnRH vaccination, suggesting a compensatory response via the neutralization of GnRH antibodies. The AMH levels did not significantly change in the postgroup, indicating the partial suppression of AMH secretion in Sertoli cells during sexual maturation and failure of Sertoli cell maturation. Thus, we successfully restrained the serum testosterone levels in cryptorchid bulls using antiGnRH vaccine. The testosterone levels are a useful indicator of the immunocastration effect on cryptorchid bulls. Hereafter, a vaccine program that can sustain the castration effect on cryptorchid bulls is necessary. The Japanese Society of Veterinary Science 2023-03-16 2023-05 /pmc/articles/PMC10209463/ /pubmed/36927961 http://dx.doi.org/10.1292/jvms.22-0571 Text en ©2023 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Theriogenology
GOTO, Akira
YOSHIDA, Nanako
NAKADA, Ken
INOUE, Yoichi
HISAEDA, Keiichi
INABA, Toshio
DOMOTO, Nanami
ISHIGURO, Yuki
ITOH, Megumi
TAKAHASHI, Eiji
SASAKI, Motoki
MATSUI, Motozumi
Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title_full Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title_fullStr Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title_full_unstemmed Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title_short Efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
title_sort efficiency of immunocastration with an anti-gonadotropin-releasing hormone vaccine on cryptorchid bulls
topic Theriogenology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209463/
https://www.ncbi.nlm.nih.gov/pubmed/36927961
http://dx.doi.org/10.1292/jvms.22-0571
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