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A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases

BACKGROUND: Mucin disulfide cross-links mediate pathologic mucus formation in muco-obstructive lung diseases. MUC-031, a novel thiol-modified carbohydrate compound, cleaves disulfides to cause mucolysis. The aim of this study was to determine the mucolytic and therapeutic effects of MUC-031 in sputu...

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Detalles Bibliográficos
Autores principales:	Addante, Annalisa, Raymond, Wilfred, Gitlin, Irina, Charbit, Annabelle, Orain, Xavier, Scheffler, Aaron Wolfe, Kuppe, Aditi, Duerr, Julia, Daniltchenko, Maria, Drescher, Marika, Graeber, Simon Y., Healy, Anne-Marie, Oscarson, Stefan, Fahy, John V., Mall, Marcus A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2023
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209473/ https://www.ncbi.nlm.nih.gov/pubmed/37080569 http://dx.doi.org/10.1183/13993003.02022-2022

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