Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab

A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children....

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Detalles Bibliográficos
Autores principales: Beck-Nielsen, Signe Sparre, Hasle, Henrik, Safwat, Akmal, Valancius, Kestutis, Langdahl, Bente, Hansen, Ebbe Stender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209478/
https://www.ncbi.nlm.nih.gov/pubmed/37250205
http://dx.doi.org/10.1016/j.bonr.2023.101687
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author Beck-Nielsen, Signe Sparre
Hasle, Henrik
Safwat, Akmal
Valancius, Kestutis
Langdahl, Bente
Hansen, Ebbe Stender
author_facet Beck-Nielsen, Signe Sparre
Hasle, Henrik
Safwat, Akmal
Valancius, Kestutis
Langdahl, Bente
Hansen, Ebbe Stender
author_sort Beck-Nielsen, Signe Sparre
collection PubMed
description A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone.
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spelling pubmed-102094782023-05-26 Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab Beck-Nielsen, Signe Sparre Hasle, Henrik Safwat, Akmal Valancius, Kestutis Langdahl, Bente Hansen, Ebbe Stender Bone Rep Case Report A giant cell tumour of bone presented in the os sacrum of a prepubertal girl. Surgery with reconstruction was performed, but total resection was impossible. Zoledronate failed to avoid tumour regrowth, and treatment was changed to denosumab, despite not being recommended for use in growing children. Denosumab treatment for 21 months reduced and stabilized tumour size, the girl became pain free with asymptomatic side effects as mild hypocalcemia, hypophosphatemia and sclerosis of newly formed bone. Elsevier 2023-05-19 /pmc/articles/PMC10209478/ /pubmed/37250205 http://dx.doi.org/10.1016/j.bonr.2023.101687 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Beck-Nielsen, Signe Sparre
Hasle, Henrik
Safwat, Akmal
Valancius, Kestutis
Langdahl, Bente
Hansen, Ebbe Stender
Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title_full Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title_fullStr Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title_full_unstemmed Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title_short Giant cell tumour of bone in os sacrum of a prepubertal girl – Surgical and medical treatment with zoledronate and denosumab
title_sort giant cell tumour of bone in os sacrum of a prepubertal girl – surgical and medical treatment with zoledronate and denosumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209478/
https://www.ncbi.nlm.nih.gov/pubmed/37250205
http://dx.doi.org/10.1016/j.bonr.2023.101687
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