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Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused
We assessed 1) trends in prevalence, awareness, treatment and control rates of dyslipidaemia and associated factors, 2) the effect of statin generation/potency on control levels and 3) the effect of ESC lipid guidelines, on lipid management. Data from multiple cross-sectional, population-based surve...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209490/ https://www.ncbi.nlm.nih.gov/pubmed/37250185 http://dx.doi.org/10.1016/j.ijcrp.2023.200187 |
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author | Marques-Vidal, Pedro Chekanova, Valeriya de Mestral, Carlos Guessous, Idris Stringhini, Silvia |
author_facet | Marques-Vidal, Pedro Chekanova, Valeriya de Mestral, Carlos Guessous, Idris Stringhini, Silvia |
author_sort | Marques-Vidal, Pedro |
collection | PubMed |
description | We assessed 1) trends in prevalence, awareness, treatment and control rates of dyslipidaemia and associated factors, 2) the effect of statin generation/potency on control levels and 3) the effect of ESC lipid guidelines, on lipid management. Data from multiple cross-sectional, population-based surveys conducted between 2005 and 2019 in the canton of Geneva, Switzerland, were used. Prevalence, awareness, treatment and control rates of dyslipidaemia were 46.0% and 34.9% (p < 0.001), 67.0% and 77.3% (p = 0.124), 40.0% and 19.9% (p < 0.001), and 68.0% and 84.0% (p = 0.255), in 2005 and 2019, respectively. After multivariable adjustment, only the decrease in treatment rates was significant. Increasing age, higher BMI, history of hypertension or diabetes were positively associated with prevalence, while female sex was negatively associated. Female sex, history of diabetes or CVD were positively associated with awareness, while increasing age was negatively associated. Increasing age, smoking, higher BMI, history of hypertension, diabetes or CVD were positively associated with treatment, while female sex was negatively associated. Female sex was positively associated with control, while increasing age was negatively associated. Highly potent statins increased from 50.0% to 87.5% and third generation statins from 0% to 47.5% in 2009 and 2015, respectively. Increased statin potency was borderline (p = 0.059) associated with dyslipidaemia control. ESC guidelines had no effect regarding the prescription of more potent or higher generation statins. We conclude that in the canton of Geneva, treatment of diagnosed dyslipidaemia is low, but control is adequate. Women are undertreated but better controlled than men. The most potent hypolipidemic drugs are underused. |
format | Online Article Text |
id | pubmed-10209490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102094902023-05-26 Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused Marques-Vidal, Pedro Chekanova, Valeriya de Mestral, Carlos Guessous, Idris Stringhini, Silvia Int J Cardiol Cardiovasc Risk Prev Research Paper We assessed 1) trends in prevalence, awareness, treatment and control rates of dyslipidaemia and associated factors, 2) the effect of statin generation/potency on control levels and 3) the effect of ESC lipid guidelines, on lipid management. Data from multiple cross-sectional, population-based surveys conducted between 2005 and 2019 in the canton of Geneva, Switzerland, were used. Prevalence, awareness, treatment and control rates of dyslipidaemia were 46.0% and 34.9% (p < 0.001), 67.0% and 77.3% (p = 0.124), 40.0% and 19.9% (p < 0.001), and 68.0% and 84.0% (p = 0.255), in 2005 and 2019, respectively. After multivariable adjustment, only the decrease in treatment rates was significant. Increasing age, higher BMI, history of hypertension or diabetes were positively associated with prevalence, while female sex was negatively associated. Female sex, history of diabetes or CVD were positively associated with awareness, while increasing age was negatively associated. Increasing age, smoking, higher BMI, history of hypertension, diabetes or CVD were positively associated with treatment, while female sex was negatively associated. Female sex was positively associated with control, while increasing age was negatively associated. Highly potent statins increased from 50.0% to 87.5% and third generation statins from 0% to 47.5% in 2009 and 2015, respectively. Increased statin potency was borderline (p = 0.059) associated with dyslipidaemia control. ESC guidelines had no effect regarding the prescription of more potent or higher generation statins. We conclude that in the canton of Geneva, treatment of diagnosed dyslipidaemia is low, but control is adequate. Women are undertreated but better controlled than men. The most potent hypolipidemic drugs are underused. Elsevier 2023-05-19 /pmc/articles/PMC10209490/ /pubmed/37250185 http://dx.doi.org/10.1016/j.ijcrp.2023.200187 Text en © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Paper Marques-Vidal, Pedro Chekanova, Valeriya de Mestral, Carlos Guessous, Idris Stringhini, Silvia Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title | Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title_full | Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title_fullStr | Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title_full_unstemmed | Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title_short | Trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of Geneva, 2005–2019: Potent statins are underused |
title_sort | trends and determinants of prevalence, awareness, treatment and control of dyslipidaemia in canton of geneva, 2005–2019: potent statins are underused |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209490/ https://www.ncbi.nlm.nih.gov/pubmed/37250185 http://dx.doi.org/10.1016/j.ijcrp.2023.200187 |
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