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New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile

A series of novel 1,3,4-thiadiazoles was synthesized via the reaction of N-(5-(2-cyanoacetamido)-1,3,4-thiadiazol-2-yl)benzamide (3) with different carbon electrophiles and evaluated as potential anticancer agents. The chemical structures of these derivatives were fully elucidated using various spec...

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Detalles Bibliográficos
Autores principales:	Hekal, Mohamed H., Farag, Paula S., Hemdan, Magdy M., El-Sayed, Amira A., Hassaballah, Aya I., El-Sayed, Wael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209631/ https://www.ncbi.nlm.nih.gov/pubmed/37250214 http://dx.doi.org/10.1039/d3ra02716c

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