Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt

A patient with ascites received a peritoneal-venous shunt for presumed cirrhosis, however surgical specimens grew Mycobacterium tuberculosis (MTb) sensitive to all anti-tuberculous drugs. Directly-Observed-Therapy (DOT) led to improvement followed by relapse with multidrug resistant MTb (MDRTB). We...

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Detalles Bibliográficos
Autores principales: Redman, Romany M., Maughan, Timothy D., Smith, Charles B., Crossno, Peter F., Granger, Donald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209681/
https://www.ncbi.nlm.nih.gov/pubmed/37250376
http://dx.doi.org/10.1016/j.idcr.2023.e01801
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author Redman, Romany M.
Maughan, Timothy D.
Smith, Charles B.
Crossno, Peter F.
Granger, Donald L.
author_facet Redman, Romany M.
Maughan, Timothy D.
Smith, Charles B.
Crossno, Peter F.
Granger, Donald L.
author_sort Redman, Romany M.
collection PubMed
description A patient with ascites received a peritoneal-venous shunt for presumed cirrhosis, however surgical specimens grew Mycobacterium tuberculosis (MTb) sensitive to all anti-tuberculous drugs. Directly-Observed-Therapy (DOT) led to improvement followed by relapse with multidrug resistant MTb (MDRTB). We discuss pathways for selection of MDRTB within mycobacterial biofilm. This case illustrates the potential for development of MDRTB in patients with long-term indwelling catheters. We emphasize catheter removal and if not possible continuing follow-up for symptoms and signs of relapse.
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spelling pubmed-102096812023-05-26 Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt Redman, Romany M. Maughan, Timothy D. Smith, Charles B. Crossno, Peter F. Granger, Donald L. IDCases Case Report A patient with ascites received a peritoneal-venous shunt for presumed cirrhosis, however surgical specimens grew Mycobacterium tuberculosis (MTb) sensitive to all anti-tuberculous drugs. Directly-Observed-Therapy (DOT) led to improvement followed by relapse with multidrug resistant MTb (MDRTB). We discuss pathways for selection of MDRTB within mycobacterial biofilm. This case illustrates the potential for development of MDRTB in patients with long-term indwelling catheters. We emphasize catheter removal and if not possible continuing follow-up for symptoms and signs of relapse. Elsevier 2023-05-18 /pmc/articles/PMC10209681/ /pubmed/37250376 http://dx.doi.org/10.1016/j.idcr.2023.e01801 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Redman, Romany M.
Maughan, Timothy D.
Smith, Charles B.
Crossno, Peter F.
Granger, Donald L.
Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title_full Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title_fullStr Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title_full_unstemmed Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title_short Development of multidrug-resistant Mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
title_sort development of multidrug-resistant mycobacterium tuberculosis in the biofilm of a peritoneal-venous shunt
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209681/
https://www.ncbi.nlm.nih.gov/pubmed/37250376
http://dx.doi.org/10.1016/j.idcr.2023.e01801
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