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The effects of macronutrients metabolism on cellular and organismal aging
Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chang Gung University
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209809/ https://www.ncbi.nlm.nih.gov/pubmed/36801257 http://dx.doi.org/10.1016/j.bj.2023.02.005 |
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author | Nehme, Jamil Altulea, Abdullah Gheorghe, Teodora Demaria, Marco |
author_facet | Nehme, Jamil Altulea, Abdullah Gheorghe, Teodora Demaria, Marco |
author_sort | Nehme, Jamil |
collection | PubMed |
description | Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target for metabolic interventions delaying aging is cellular senescence, a state of stable growth arrest that is accompanied by various structural and functional changes including the activation of a pro-inflammatory secretome. Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence. We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual. |
format | Online Article Text |
id | pubmed-10209809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Chang Gung University |
record_format | MEDLINE/PubMed |
spelling | pubmed-102098092023-05-26 The effects of macronutrients metabolism on cellular and organismal aging Nehme, Jamil Altulea, Abdullah Gheorghe, Teodora Demaria, Marco Biomed J Review Article Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently explored as anti-aging strategies. A common target for metabolic interventions delaying aging is cellular senescence, a state of stable growth arrest that is accompanied by various structural and functional changes including the activation of a pro-inflammatory secretome. Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence. We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual. Chang Gung University 2023-06 2023-02-16 /pmc/articles/PMC10209809/ /pubmed/36801257 http://dx.doi.org/10.1016/j.bj.2023.02.005 Text en © 2023 Chang Gung University https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Nehme, Jamil Altulea, Abdullah Gheorghe, Teodora Demaria, Marco The effects of macronutrients metabolism on cellular and organismal aging |
title | The effects of macronutrients metabolism on cellular and organismal aging |
title_full | The effects of macronutrients metabolism on cellular and organismal aging |
title_fullStr | The effects of macronutrients metabolism on cellular and organismal aging |
title_full_unstemmed | The effects of macronutrients metabolism on cellular and organismal aging |
title_short | The effects of macronutrients metabolism on cellular and organismal aging |
title_sort | effects of macronutrients metabolism on cellular and organismal aging |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209809/ https://www.ncbi.nlm.nih.gov/pubmed/36801257 http://dx.doi.org/10.1016/j.bj.2023.02.005 |
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