Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties

Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results s...

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Detalles Bibliográficos
Autores principales: Taj, M. B., Raheel, A., Alelwani, W., Alnajeebi, A. M., Alnoman, R. B., Javed, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209927/
https://www.ncbi.nlm.nih.gov/pubmed/37252637
http://dx.doi.org/10.1134/S1070363223040199
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author Taj, M. B.
Raheel, A.
Alelwani, W.
Alnajeebi, A. M.
Alnoman, R. B.
Javed, T.
author_facet Taj, M. B.
Raheel, A.
Alelwani, W.
Alnajeebi, A. M.
Alnoman, R. B.
Javed, T.
author_sort Taj, M. B.
collection PubMed
description Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that para-chloro-substituted derivative (9c) is most active with IC(50) values of 10±1.56. All three compounds 9a–9c with a maximum of 20% inhibition for ALR1 represent superior selectivity toward the targeted ALR2 to act as a lead in the search for new antidiabetic agents.
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spelling pubmed-102099272023-05-26 Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties Taj, M. B. Raheel, A. Alelwani, W. Alnajeebi, A. M. Alnoman, R. B. Javed, T. Russ J Gen Chem Article Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were subjected to potential antidiabetic activity. The results showed that para-chloro-substituted derivative (9c) is most active with IC(50) values of 10±1.56. All three compounds 9a–9c with a maximum of 20% inhibition for ALR1 represent superior selectivity toward the targeted ALR2 to act as a lead in the search for new antidiabetic agents. Pleiades Publishing 2023-05-25 2023 /pmc/articles/PMC10209927/ /pubmed/37252637 http://dx.doi.org/10.1134/S1070363223040199 Text en © Pleiades Publishing, Ltd. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Taj, M. B.
Raheel, A.
Alelwani, W.
Alnajeebi, A. M.
Alnoman, R. B.
Javed, T.
Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title_full Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title_fullStr Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title_full_unstemmed Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title_short Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
title_sort mechanochemical synthesis of thiazolidinone-triazoles derivatives as antidiabetic agents: pharmacokinetics, molecular docking, and in vitro antidiabetic properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209927/
https://www.ncbi.nlm.nih.gov/pubmed/37252637
http://dx.doi.org/10.1134/S1070363223040199
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