Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis

Drawing on ethical and legal frameworks in the Netherlands, the United States and France, we examine whether physicians are expected to inform patients about potentially relevant opportunities for expanded access to investigational drugs. While we found no definitive legal obligation, we argue that...

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Autores principales: Vermeulen, Stefan F., Hordijk, Marjolijn, Visser, Ruben J., Bunnik, Eline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Independent Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209970/
https://www.ncbi.nlm.nih.gov/pubmed/37226748
http://dx.doi.org/10.1017/jme.2023.53
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author Vermeulen, Stefan F.
Hordijk, Marjolijn
Visser, Ruben J.
Bunnik, Eline M.
author_facet Vermeulen, Stefan F.
Hordijk, Marjolijn
Visser, Ruben J.
Bunnik, Eline M.
author_sort Vermeulen, Stefan F.
collection PubMed
description Drawing on ethical and legal frameworks in the Netherlands, the United States and France, we examine whether physicians are expected to inform patients about potentially relevant opportunities for expanded access to investigational drugs. While we found no definitive legal obligation, we argue that physicians have a moral obligation to discuss opportunities for expanded access with patients who have run out of treatment options to prevent inequality, to promote autonomy, and to achieve beneficence.
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spelling pubmed-102099702023-05-26 Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis Vermeulen, Stefan F. Hordijk, Marjolijn Visser, Ruben J. Bunnik, Eline M. J Law Med Ethics Independent Articles Drawing on ethical and legal frameworks in the Netherlands, the United States and France, we examine whether physicians are expected to inform patients about potentially relevant opportunities for expanded access to investigational drugs. While we found no definitive legal obligation, we argue that physicians have a moral obligation to discuss opportunities for expanded access with patients who have run out of treatment options to prevent inequality, to promote autonomy, and to achieve beneficence. Cambridge University Press 2023 /pmc/articles/PMC10209970/ /pubmed/37226748 http://dx.doi.org/10.1017/jme.2023.53 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Independent Articles
Vermeulen, Stefan F.
Hordijk, Marjolijn
Visser, Ruben J.
Bunnik, Eline M.
Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title_full Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title_fullStr Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title_full_unstemmed Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title_short Do Physicians Have a Duty to Discuss Expanded Access to Investigational Drugs with their Patients? A Normative Analysis
title_sort do physicians have a duty to discuss expanded access to investigational drugs with their patients? a normative analysis
topic Independent Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209970/
https://www.ncbi.nlm.nih.gov/pubmed/37226748
http://dx.doi.org/10.1017/jme.2023.53
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