Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme

[Image: see text] A new series of thiazole central scaffold-based small molecules of hLDHA inhibitors were designed using an in silico approach. Molecular docking analysis of designed molecules with hLDHA (PDB ID: 1I10) demonstrates that Ala 29, Val 30, Arg 98, Gln 99, Gly 96, and Thr 94 possessed s...

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Detalles Bibliográficos
Autores principales: Sharma, Dolly, Singh, Mamta, Joshi, Jayadev, Garg, Manoj, Chaudhary, Vidhi, Blankenberg, Daniel, Chandna, Sudhir, Kumar, Vinit, Rani, Reshma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210175/
https://www.ncbi.nlm.nih.gov/pubmed/37251149
http://dx.doi.org/10.1021/acsomega.2c07569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210175/
https://www.ncbi.nlm.nih.gov/pubmed/37251149
http://dx.doi.org/10.1021/acsomega.2c07569

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