Cargando…

Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1

Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally. We find that the transition from early to late progenitor compet...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jianmin, Roberts, Jacqueline M., Chang, Fei, Schwakopf, Joon, Vetter, Monica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210259/
https://www.ncbi.nlm.nih.gov/pubmed/36924502
http://dx.doi.org/10.1016/j.celrep.2023.112237
_version_ 1785047031942742016
author Zhang, Jianmin
Roberts, Jacqueline M.
Chang, Fei
Schwakopf, Joon
Vetter, Monica L.
author_facet Zhang, Jianmin
Roberts, Jacqueline M.
Chang, Fei
Schwakopf, Joon
Vetter, Monica L.
author_sort Zhang, Jianmin
collection PubMed
description Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally. We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extended production of early cell types and extended expression of early progenitor genes. Jarid2 can regulate histone modifications, and we find reduction of repressive mark H3K27me3 on a subset of early progenitor genes with loss of Jarid2, most notably Foxp1. We show that Foxp1 regulates the competence to generate early-born retinal cell types, promotes early and represses late progenitor gene expression, and is required for extending early retinal cell production after loss of Jarid2. We conclude that Jarid2 facilitates progression of retinal progenitor temporal identity by repressing Foxp1, which is a primary regulator of early temporal patterning.
format Online
Article
Text
id pubmed-10210259
institution National Center for Biotechnology Information
language English
publishDate 2023
record_format MEDLINE/PubMed
spelling pubmed-102102592023-05-25 Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1 Zhang, Jianmin Roberts, Jacqueline M. Chang, Fei Schwakopf, Joon Vetter, Monica L. Cell Rep Article Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally. We find that the transition from early to late progenitor competence is regulated by Jarid2. Loss of Jarid2 results in extended production of early cell types and extended expression of early progenitor genes. Jarid2 can regulate histone modifications, and we find reduction of repressive mark H3K27me3 on a subset of early progenitor genes with loss of Jarid2, most notably Foxp1. We show that Foxp1 regulates the competence to generate early-born retinal cell types, promotes early and represses late progenitor gene expression, and is required for extending early retinal cell production after loss of Jarid2. We conclude that Jarid2 facilitates progression of retinal progenitor temporal identity by repressing Foxp1, which is a primary regulator of early temporal patterning. 2023-03-28 2023-03-14 /pmc/articles/PMC10210259/ /pubmed/36924502 http://dx.doi.org/10.1016/j.celrep.2023.112237 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Zhang, Jianmin
Roberts, Jacqueline M.
Chang, Fei
Schwakopf, Joon
Vetter, Monica L.
Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title_full Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title_fullStr Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title_full_unstemmed Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title_short Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
title_sort jarid2 promotes temporal progression of retinal progenitors via repression of foxp1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210259/
https://www.ncbi.nlm.nih.gov/pubmed/36924502
http://dx.doi.org/10.1016/j.celrep.2023.112237
work_keys_str_mv AT zhangjianmin jarid2promotestemporalprogressionofretinalprogenitorsviarepressionoffoxp1
AT robertsjacquelinem jarid2promotestemporalprogressionofretinalprogenitorsviarepressionoffoxp1
AT changfei jarid2promotestemporalprogressionofretinalprogenitorsviarepressionoffoxp1
AT schwakopfjoon jarid2promotestemporalprogressionofretinalprogenitorsviarepressionoffoxp1
AT vettermonical jarid2promotestemporalprogressionofretinalprogenitorsviarepressionoffoxp1