The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study

BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and induce headache and migraine. Our objective was to determ...

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Detalles Bibliográficos
Autores principales: Rasmussen, Nadja Bredo, Deligianni, Christina, Christensen, Casper Emil, Karlsson, William Kristian, Al-Khazali, Haidar Muhsen, Van de Casteele, Tom, Granhall, Charlotte, Amin, Faisal Mohammad, Ashina, Messoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210362/
https://www.ncbi.nlm.nih.gov/pubmed/37231350
http://dx.doi.org/10.1186/s10194-023-01599-w

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