Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases

Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative t...

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Autores principales: Sun, Mingchu, Jiang, Wenhua, Mu, Nan, Zhang, Zihui, Yu, Lu, Ma, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210445/
https://www.ncbi.nlm.nih.gov/pubmed/37231493
http://dx.doi.org/10.1186/s12967-023-04203-6
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author Sun, Mingchu
Jiang, Wenhua
Mu, Nan
Zhang, Zihui
Yu, Lu
Ma, Heng
author_facet Sun, Mingchu
Jiang, Wenhua
Mu, Nan
Zhang, Zihui
Yu, Lu
Ma, Heng
author_sort Sun, Mingchu
collection PubMed
description Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD. Here, we review the mitochondrial abnormalities that occur in CVD and summarize the therapeutic strategies of mitochondrial transplantation for CVD.
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spelling pubmed-102104452023-05-26 Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases Sun, Mingchu Jiang, Wenhua Mu, Nan Zhang, Zihui Yu, Lu Ma, Heng J Transl Med Review Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD. Here, we review the mitochondrial abnormalities that occur in CVD and summarize the therapeutic strategies of mitochondrial transplantation for CVD. BioMed Central 2023-05-25 /pmc/articles/PMC10210445/ /pubmed/37231493 http://dx.doi.org/10.1186/s12967-023-04203-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Mingchu
Jiang, Wenhua
Mu, Nan
Zhang, Zihui
Yu, Lu
Ma, Heng
Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title_full Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title_fullStr Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title_full_unstemmed Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title_short Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
title_sort mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210445/
https://www.ncbi.nlm.nih.gov/pubmed/37231493
http://dx.doi.org/10.1186/s12967-023-04203-6
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