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Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre

BACKGROUND: Placental chorioangioma is a rare disorder in pregnancy. We retrospectively reviewed the perinatal complications and long-term outcomes in pregnancies with placental chorioangioma and evaluated the factors affecting disease prognosis. METHODS: We reviewed pregnant women who delivered at...

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Autores principales: Ma, Hongwei, Liu, Ziling, Ruan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210461/
https://www.ncbi.nlm.nih.gov/pubmed/37231382
http://dx.doi.org/10.1186/s12884-023-05719-x
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author Ma, Hongwei
Liu, Ziling
Ruan, Jie
author_facet Ma, Hongwei
Liu, Ziling
Ruan, Jie
author_sort Ma, Hongwei
collection PubMed
description BACKGROUND: Placental chorioangioma is a rare disorder in pregnancy. We retrospectively reviewed the perinatal complications and long-term outcomes in pregnancies with placental chorioangioma and evaluated the factors affecting disease prognosis. METHODS: We reviewed pregnant women who delivered at our hospital in the past decade and whose diagnosis of placental chorioangioma was confirmed by pathological diagnosis. Information on maternal demographics, prenatal sonographic findings and perinatal outcomes was obtained by reviewing the medical records. In the latter part of the study, follow-up of children was conducted by phone interview. RESULTS: In the 10 years from August 2008 to December 2018, 175 cases(0.17%) were identified as placental chorioangioma histologically and 44(0.04%) of them were large chorioangiomas. Nearly one-third of cases with large chorioangiomas were associated with severe maternal and fetal complications or required prenatal intervention. Although one-fifth of fetuses/newborns complicated with large chorioangiomas were lost perinatally, the long-term prognosis for surviving fetuses was generally good. Further statistical analysis revealed that tumor size and location affect prognosis. CONCLUSION: Placental chorioangioma may cause an unfavorable perinatal outcome. Regular ultrasound monitoring can provide the tumor characteristics which can be referred to for predicting the tendency of those complications and indicate when intervention may be necessary. It is not clear which factors lead to complications with fetal damage as the main manifestation or polyhydramnios as the main manifestation.
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spelling pubmed-102104612023-05-26 Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre Ma, Hongwei Liu, Ziling Ruan, Jie BMC Pregnancy Childbirth Research BACKGROUND: Placental chorioangioma is a rare disorder in pregnancy. We retrospectively reviewed the perinatal complications and long-term outcomes in pregnancies with placental chorioangioma and evaluated the factors affecting disease prognosis. METHODS: We reviewed pregnant women who delivered at our hospital in the past decade and whose diagnosis of placental chorioangioma was confirmed by pathological diagnosis. Information on maternal demographics, prenatal sonographic findings and perinatal outcomes was obtained by reviewing the medical records. In the latter part of the study, follow-up of children was conducted by phone interview. RESULTS: In the 10 years from August 2008 to December 2018, 175 cases(0.17%) were identified as placental chorioangioma histologically and 44(0.04%) of them were large chorioangiomas. Nearly one-third of cases with large chorioangiomas were associated with severe maternal and fetal complications or required prenatal intervention. Although one-fifth of fetuses/newborns complicated with large chorioangiomas were lost perinatally, the long-term prognosis for surviving fetuses was generally good. Further statistical analysis revealed that tumor size and location affect prognosis. CONCLUSION: Placental chorioangioma may cause an unfavorable perinatal outcome. Regular ultrasound monitoring can provide the tumor characteristics which can be referred to for predicting the tendency of those complications and indicate when intervention may be necessary. It is not clear which factors lead to complications with fetal damage as the main manifestation or polyhydramnios as the main manifestation. BioMed Central 2023-05-25 /pmc/articles/PMC10210461/ /pubmed/37231382 http://dx.doi.org/10.1186/s12884-023-05719-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ma, Hongwei
Liu, Ziling
Ruan, Jie
Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title_full Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title_fullStr Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title_full_unstemmed Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title_short Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
title_sort placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210461/
https://www.ncbi.nlm.nih.gov/pubmed/37231382
http://dx.doi.org/10.1186/s12884-023-05719-x
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