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Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience

Idiopathic unilateral breast enlargement (UBE) in males is a, commonly overlooked, diagnosis of exclusion that requires careful history, meticulous physical examination, and pertinent laboratory studies to exclude the possible pathologic causes. The aims of the present update are to review the curre...

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Autores principales: De Sanctis, Vincenzo, Soliman, Ashraf T, Tzoulis, Ploutarchos, Daar, Shahina, Di Maio, Salvatore, Kattamis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210567/
https://www.ncbi.nlm.nih.gov/pubmed/37092615
http://dx.doi.org/10.23750/abm.v94i2.14324
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author De Sanctis, Vincenzo
Soliman, Ashraf T
Tzoulis, Ploutarchos
Daar, Shahina
Di Maio, Salvatore
Kattamis, Christos
author_facet De Sanctis, Vincenzo
Soliman, Ashraf T
Tzoulis, Ploutarchos
Daar, Shahina
Di Maio, Salvatore
Kattamis, Christos
author_sort De Sanctis, Vincenzo
collection PubMed
description Idiopathic unilateral breast enlargement (UBE) in males is a, commonly overlooked, diagnosis of exclusion that requires careful history, meticulous physical examination, and pertinent laboratory studies to exclude the possible pathologic causes. The aims of the present update are to review the current literature on UBE in subjects during adolescent age (10-19 years) in 18 cases, and to report the personal experience in 13 adolescents referred to our unit during the last four decades. In total, our survey and personal experience include 31 UBE cases, 10 of whom (32.2%) being idiopathic or familial gynecomastia (GM). In 3/31 (9.6%) UBE was due to breast sarcoma/ carcinoma; one patient (11-years old) had a 5-year history of painless lump in the right breast, which increased gradually in size followed by bloody nipple discharge. In the personal cases of 13 adolescents, a moderate to marked UBE was secondary to: treatment with androgens (2 β-thalassemic patients with hypogonadism), high estrogen/androgen ratio in 2 Klinefelter syndrome patients, peripheral aromatization of androgens in 1 patient with non-classical 21-hydroxylase deficiency (NC-21-OH-D). One patient had subareolar hematoma due to injury. In 2 patients (15,3%) marked UBE was due to cystic lymphangioma (histologically proved). Furthermore, 5 patients were characterized as idiopathic UBE In clinical practice, the persistence of UBE for long period before diagnosis necessitates attention and further evaluation. Underlying causes should be treated, when possible, while surgery can be offered to patients with persistent or atypical signs and/or symptoms of UBE. For the optimal management of this condition, better collaboration between primary care physician and specialists is mandatory. (www.actabiomedica.it)
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spelling pubmed-102105672023-05-26 Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience De Sanctis, Vincenzo Soliman, Ashraf T Tzoulis, Ploutarchos Daar, Shahina Di Maio, Salvatore Kattamis, Christos Acta Biomed Pediatric and Adolescent Endocrinology Update: Review Idiopathic unilateral breast enlargement (UBE) in males is a, commonly overlooked, diagnosis of exclusion that requires careful history, meticulous physical examination, and pertinent laboratory studies to exclude the possible pathologic causes. The aims of the present update are to review the current literature on UBE in subjects during adolescent age (10-19 years) in 18 cases, and to report the personal experience in 13 adolescents referred to our unit during the last four decades. In total, our survey and personal experience include 31 UBE cases, 10 of whom (32.2%) being idiopathic or familial gynecomastia (GM). In 3/31 (9.6%) UBE was due to breast sarcoma/ carcinoma; one patient (11-years old) had a 5-year history of painless lump in the right breast, which increased gradually in size followed by bloody nipple discharge. In the personal cases of 13 adolescents, a moderate to marked UBE was secondary to: treatment with androgens (2 β-thalassemic patients with hypogonadism), high estrogen/androgen ratio in 2 Klinefelter syndrome patients, peripheral aromatization of androgens in 1 patient with non-classical 21-hydroxylase deficiency (NC-21-OH-D). One patient had subareolar hematoma due to injury. In 2 patients (15,3%) marked UBE was due to cystic lymphangioma (histologically proved). Furthermore, 5 patients were characterized as idiopathic UBE In clinical practice, the persistence of UBE for long period before diagnosis necessitates attention and further evaluation. Underlying causes should be treated, when possible, while surgery can be offered to patients with persistent or atypical signs and/or symptoms of UBE. For the optimal management of this condition, better collaboration between primary care physician and specialists is mandatory. (www.actabiomedica.it) Mattioli 1885 2023 2023-04-24 /pmc/articles/PMC10210567/ /pubmed/37092615 http://dx.doi.org/10.23750/abm.v94i2.14324 Text en Copyright: © 2023 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Pediatric and Adolescent Endocrinology Update: Review
De Sanctis, Vincenzo
Soliman, Ashraf T
Tzoulis, Ploutarchos
Daar, Shahina
Di Maio, Salvatore
Kattamis, Christos
Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title_full Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title_fullStr Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title_full_unstemmed Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title_short Unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
title_sort unilateral breast enlargement in males during adolescence (10-19 years): review of current literature and personal experience
topic Pediatric and Adolescent Endocrinology Update: Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210567/
https://www.ncbi.nlm.nih.gov/pubmed/37092615
http://dx.doi.org/10.23750/abm.v94i2.14324
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