Phylogenetic Comparative Analysis of Single-Cell Transcriptomes Reveals Constrained Accumulation of Gene Expression Heterogeneity during Clonal Expansion

In the same way that a phylogeny summarizes the evolutionary history of species, a cell lineage tree describes the process of clonal expansion, in which gene expression differences between cells naturally accrue as a result of stochastic partitioning and imperfect expression control. How is function...

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Detalles Bibliográficos
Autores principales: Chen, Feng, Li, Zizhang, Zhang, Xiaoyu, Wu, Peng, Yang, Wenjing, Yang, Junnan, Chen, Xiaoshu, Yang, Jian-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210624/
https://www.ncbi.nlm.nih.gov/pubmed/37183780
http://dx.doi.org/10.1093/molbev/msad113

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