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Oxazolidinones as versatile scaffolds in medicinal chemistry

Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharm...

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Autores principales: Fernandes, Guilherme Felipe Santos, Scarim, Cauê Benito, Kim, Seong-Heun, Wu, Jingyue, Castagnolo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211318/
https://www.ncbi.nlm.nih.gov/pubmed/37252095
http://dx.doi.org/10.1039/d2md00415a
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author Fernandes, Guilherme Felipe Santos
Scarim, Cauê Benito
Kim, Seong-Heun
Wu, Jingyue
Castagnolo, Daniele
author_facet Fernandes, Guilherme Felipe Santos
Scarim, Cauê Benito
Kim, Seong-Heun
Wu, Jingyue
Castagnolo, Daniele
author_sort Fernandes, Guilherme Felipe Santos
collection PubMed
description Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry.
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spelling pubmed-102113182023-05-26 Oxazolidinones as versatile scaffolds in medicinal chemistry Fernandes, Guilherme Felipe Santos Scarim, Cauê Benito Kim, Seong-Heun Wu, Jingyue Castagnolo, Daniele RSC Med Chem Chemistry Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry. RSC 2023-02-08 /pmc/articles/PMC10211318/ /pubmed/37252095 http://dx.doi.org/10.1039/d2md00415a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Fernandes, Guilherme Felipe Santos
Scarim, Cauê Benito
Kim, Seong-Heun
Wu, Jingyue
Castagnolo, Daniele
Oxazolidinones as versatile scaffolds in medicinal chemistry
title Oxazolidinones as versatile scaffolds in medicinal chemistry
title_full Oxazolidinones as versatile scaffolds in medicinal chemistry
title_fullStr Oxazolidinones as versatile scaffolds in medicinal chemistry
title_full_unstemmed Oxazolidinones as versatile scaffolds in medicinal chemistry
title_short Oxazolidinones as versatile scaffolds in medicinal chemistry
title_sort oxazolidinones as versatile scaffolds in medicinal chemistry
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211318/
https://www.ncbi.nlm.nih.gov/pubmed/37252095
http://dx.doi.org/10.1039/d2md00415a
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