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Oxazolidinones as versatile scaffolds in medicinal chemistry
Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211318/ https://www.ncbi.nlm.nih.gov/pubmed/37252095 http://dx.doi.org/10.1039/d2md00415a |
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author | Fernandes, Guilherme Felipe Santos Scarim, Cauê Benito Kim, Seong-Heun Wu, Jingyue Castagnolo, Daniele |
author_facet | Fernandes, Guilherme Felipe Santos Scarim, Cauê Benito Kim, Seong-Heun Wu, Jingyue Castagnolo, Daniele |
author_sort | Fernandes, Guilherme Felipe Santos |
collection | PubMed |
description | Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry. |
format | Online Article Text |
id | pubmed-10211318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-102113182023-05-26 Oxazolidinones as versatile scaffolds in medicinal chemistry Fernandes, Guilherme Felipe Santos Scarim, Cauê Benito Kim, Seong-Heun Wu, Jingyue Castagnolo, Daniele RSC Med Chem Chemistry Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry. RSC 2023-02-08 /pmc/articles/PMC10211318/ /pubmed/37252095 http://dx.doi.org/10.1039/d2md00415a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Fernandes, Guilherme Felipe Santos Scarim, Cauê Benito Kim, Seong-Heun Wu, Jingyue Castagnolo, Daniele Oxazolidinones as versatile scaffolds in medicinal chemistry |
title | Oxazolidinones as versatile scaffolds in medicinal chemistry |
title_full | Oxazolidinones as versatile scaffolds in medicinal chemistry |
title_fullStr | Oxazolidinones as versatile scaffolds in medicinal chemistry |
title_full_unstemmed | Oxazolidinones as versatile scaffolds in medicinal chemistry |
title_short | Oxazolidinones as versatile scaffolds in medicinal chemistry |
title_sort | oxazolidinones as versatile scaffolds in medicinal chemistry |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211318/ https://www.ncbi.nlm.nih.gov/pubmed/37252095 http://dx.doi.org/10.1039/d2md00415a |
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