Physiologically-Based Pharmacokinetic Modeling of PAXLOVID™ with First-Order Absorption Kinetics

PURPOSE: PAXLOVID™ is nirmatrelvir tablets co-packaged with ritonavir tablets. Ritonavir is used as a pharmacokinetics (PK) enhancer to reduce metabolism and increase exposure of nirmatrelvir. This is the first disclosure of Paxlovid physiologically-based pharmacokinetic (PBPK) model. METHODS: Nirma...

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Detalles Bibliográficos
Autores principales: Sagawa, Kazuko, Lin, Jian, Jaini, Rohit, Di, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212229/
https://www.ncbi.nlm.nih.gov/pubmed/37231296
http://dx.doi.org/10.1007/s11095-023-03538-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212229/
https://www.ncbi.nlm.nih.gov/pubmed/37231296
http://dx.doi.org/10.1007/s11095-023-03538-5

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