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Site I(Q) in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Superoxide/hydrogen peroxide production by site I(Q) in complex I of the electron transport chain is conventionally assayed during reverse electron transport (RET) from ubiquinol to NAD. However, S1QELs (specific suppressors of superoxide/hydrogen peroxide production by site I(Q)) have potent effect...

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Detalles Bibliográficos
Autores principales:	Gibbs, Edwin T., Lerner, Chad A., Watson, Mark A., Wong, Hoi-Shan, Gerencser, Akos A., Brand, Martin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212513/ https://www.ncbi.nlm.nih.gov/pubmed/36862427 http://dx.doi.org/10.1042/BCJ20220611

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