Cargando…

Site I(Q) in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Superoxide/hydrogen peroxide production by site I(Q) in complex I of the electron transport chain is conventionally assayed during reverse electron transport (RET) from ubiquinol to NAD. However, S1QELs (specific suppressors of superoxide/hydrogen peroxide production by site I(Q)) have potent effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gibbs, Edwin T., Lerner, Chad A., Watson, Mark A., Wong, Hoi-Shan, Gerencser, Akos A., Brand, Martin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212513/ https://www.ncbi.nlm.nih.gov/pubmed/36862427 http://dx.doi.org/10.1042/BCJ20220611

Ejemplares similares

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I: A SINGLE, UNIFIED MECHANISM THAT APPLIES DURING BOTH FORWARD AND REVERSE ELECTRON TRANSFER
por: Pryde, Kenneth R., et al.
Publicado: (2011)

Control of mitochondrial superoxide production by reverse electron transport at complex I
por: Robb, Ellen L., et al.
Publicado: (2018)

From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I
por: Sazanov, Leonid A.
Publicado: (2023)

Post-translational Modifications near the Quinone Binding Site of Mammalian Complex I
por: Carroll, Joe, et al.
Publicado: (2013)

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2016)

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na(+)/H(+) Antiporter
por: Roberts, Philippa G., et al.
Publicado: (2012)

The CcmC–CcmE interaction during cytochrome c maturation by System I is driven by protein–protein and not protein–heme contacts
por: Shevket, Shevket H., et al.
Publicado: (2018)

Mitochondrial Disease-related Mutation G167P in Cytochrome b of Rhodobacter capsulatus Cytochrome bc(1) (S151P in Human) Affects the Equilibrium Distribution of [2Fe-2S] Cluster and Generation of Superoxide
por: Borek, Arkadiusz, et al.
Publicado: (2015)

Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized
por: Jones, Andrew J. Y., et al.
Publicado: (2017)

Prescription drugs and mitochondrial metabolism
por: Schmidt, Cameron A.
Publicado: (2022)

Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site I(Q) of complex I in diverse cell lines
por: Fang, Jingqi, et al.
Publicado: (2020)

A Pivotal Heme-transfer Reaction Intermediate in Cytochrome c Biogenesis
por: Mavridou, Despoina A. I., et al.
Publicado: (2012)

Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells
por: Assis-de-Lemos, Gabriela, et al.
Publicado: (2021)

Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome
por: Hock, Daniella H., et al.
Publicado: (2020)

Cryo-EM structures of the Synechocystis sp. PCC 6803 cytochrome b(6)f complex with and without the regulatory PetP subunit
por: Proctor, Matthew S., et al.
Publicado: (2022)

Modulation of Energy Transfer Pathways between Mitochondria and Myofibrils by Changes in Performance of Perfused Heart
por: Vendelin, Marko, et al.
Publicado: (2010)

Electrostatic Ratchet in the Protective Antigen Channel Promotes Anthrax Toxin Translocation
por: Wynia-Smith, Sarah L., et al.
Publicado: (2012)

Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia
por: Handzlik, Michal K., et al.
Publicado: (2021)

Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting of Mycobacterium tuberculosis Cytochrome bcc and Mycobacterium smegmatis Cytochrome aa(3)*
por: Kim, Mi-Sun, et al.
Publicado: (2015)

ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function
por: Darshi, Manjula, et al.
Publicado: (2011)

Leigh Syndrome in Drosophila melanogaster: MORPHOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF Surf1 POST-TRANSCRIPTIONAL SILENCING
por: Da-Rè, Caterina, et al.
Publicado: (2014)

Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
por: Armstrong, Jane A., et al.
Publicado: (2018)

Functional Characterization of drim2, the Drosophila melanogaster Homolog of the Yeast Mitochondrial Deoxynucleotide Transporter
por: Da-Rè, Caterina, et al.
Publicado: (2014)

Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia
por: Chouchani, Edward T., et al.
Publicado: (2017)

Menaquinone-7 Is Specific Cofactor in Tetraheme Quinol Dehydrogenase CymA
por: McMillan, Duncan G. G., et al.
Publicado: (2012)

Molecular Dynamics Simulations of Creatine Kinase and Adenine Nucleotide Translocase in Mitochondrial Membrane Patch
por: Karo, Jaanus, et al.
Publicado: (2012)

The Antisense RNA As1_flv4 in the Cyanobacterium Synechocystis sp. PCC 6803 Prevents Premature Expression of the flv4-2 Operon upon Shift in Inorganic Carbon Supply
por: Eisenhut, Marion, et al.
Publicado: (2012)

Reconstitution of Vacuolar-type Rotary H(+)-ATPase/Synthase from Thermus thermophilus
por: Kishikawa, Jun-ichi, et al.
Publicado: (2012)

Targeting and Import Mechanism of Coiled-coil Helix Coiled-coil Helix Domain-containing Protein 3 (ChChd3) into the Mitochondrial Intermembrane Space
por: Darshi, Manjula, et al.
Publicado: (2012)

Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies
por: Shinzawa-Itoh, Kyoko, et al.
Publicado: (2016)

NdhM Subunit Is Required for the Stability and the Function of NAD(P)H Dehydrogenase Complexes Involved in CO(2) Uptake in Synechocystis sp. Strain PCC 6803
por: He, Zhihui, et al.
Publicado: (2016)

Tuning of Hemes b Equilibrium Redox Potential Is Not Required for Cross-Membrane Electron Transfer
por: Pintscher, Sebastian, et al.
Publicado: (2016)

Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers
por: Crichton, Paul G., et al.
Publicado: (2015)

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism
por: Gohil, Vishal M., et al.
Publicado: (2013)

Lipid, Detergent, and Coomassie Blue G-250 Affect the Migration of Small Membrane Proteins in Blue Native Gels: MITOCHONDRIAL CARRIERS MIGRATE AS MONOMERS NOT DIMERS
por: Crichton, Paul G., et al.
Publicado: (2013)

Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation
por: Meng, Fantao, et al.
Publicado: (2019)

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
por: Hinchy, Elizabeth C., et al.
Publicado: (2018)

X-ray structural analyses of azide-bound cytochrome c oxidases reveal that the H-pathway is critically important for the proton-pumping activity
por: Shimada, Atsuhiro, et al.
Publicado: (2018)

The structure and reactivity of the HoxEFU complex from the cyanobacterium Synechocystis sp. PCC 6803
por: Artz, Jacob H., et al.
Publicado: (2020)

CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer
por: Han, Jing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7tjtikcmscihi71noh2csi9tli