Cargando…
Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors
BACKGROUND: The presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood. Therefore, we examined whether cancer cachexia affects the prognosis of patients with no...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212657/ https://www.ncbi.nlm.nih.gov/pubmed/37037511 http://dx.doi.org/10.1111/1759-7714.14881 |
_version_ | 1785047467119607808 |
---|---|
author | Matsuo, Norikazu Azuma, Koichi Murotani, Kenta Murata, Daiki Matama, Goushi Kawahara, Akihiko Kojima, Takashi Tokito, Takaaki Hoshino, Tomoaki |
author_facet | Matsuo, Norikazu Azuma, Koichi Murotani, Kenta Murata, Daiki Matama, Goushi Kawahara, Akihiko Kojima, Takashi Tokito, Takaaki Hoshino, Tomoaki |
author_sort | Matsuo, Norikazu |
collection | PubMed |
description | BACKGROUND: The presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood. Therefore, we examined whether cancer cachexia affects the prognosis of patients with non‐small cell lung cancer (NSCLC) treated with PD‐1/PD‐L1 inhibitors. METHODS: We retrospectively screened patients with pathologically confirmed advanced or recurrent NSCLC who were treated with PD‐1/PD‐L1 monotherapy at Kurume University Hospital. We defined cancer cachexia as weight loss of at least 5% during the past 6 months or any degree of weight loss more than 2% and BMI <20. RESULTS: Among 182 patients, 74 had cancer cachexia. The presence of cachexia was significantly associated with females, poor performance status (PS), never‐smokers, and driver mutations. Multivariate analysis revealed that poor PS and being a smoker were associated with the presence of cachexia. Patients with cancer cachexia had significantly shorter progression‐free survival (PFS) and overall survival (OS). In the multivariate analysis, PS and sex were significantly correlated with PFS, whereas PS and cachexia were significantly correlated with OS. Subanalysis revealed that patients in the PS0/without cachexia group had longer PFS and OS than those in the cachexia or PS1‐3 group. CONCLUSIONS: In NSCLC patients, cachexia was associated with a worse prognosis, irrespective of tumor PD‐L1 expression, indicating that cachexia is a predictive factor for NSCLC patients receiving immune checkpoint inhibitors. |
format | Online Article Text |
id | pubmed-10212657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102126572023-05-26 Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors Matsuo, Norikazu Azuma, Koichi Murotani, Kenta Murata, Daiki Matama, Goushi Kawahara, Akihiko Kojima, Takashi Tokito, Takaaki Hoshino, Tomoaki Thorac Cancer Original Articles BACKGROUND: The presence of cachexia in cancer patients negatively affects the quality of life and survival. However, the impact of cachexia on immunotherapy, such as PD‐1/L1 inhibitors, is not fully understood. Therefore, we examined whether cancer cachexia affects the prognosis of patients with non‐small cell lung cancer (NSCLC) treated with PD‐1/PD‐L1 inhibitors. METHODS: We retrospectively screened patients with pathologically confirmed advanced or recurrent NSCLC who were treated with PD‐1/PD‐L1 monotherapy at Kurume University Hospital. We defined cancer cachexia as weight loss of at least 5% during the past 6 months or any degree of weight loss more than 2% and BMI <20. RESULTS: Among 182 patients, 74 had cancer cachexia. The presence of cachexia was significantly associated with females, poor performance status (PS), never‐smokers, and driver mutations. Multivariate analysis revealed that poor PS and being a smoker were associated with the presence of cachexia. Patients with cancer cachexia had significantly shorter progression‐free survival (PFS) and overall survival (OS). In the multivariate analysis, PS and sex were significantly correlated with PFS, whereas PS and cachexia were significantly correlated with OS. Subanalysis revealed that patients in the PS0/without cachexia group had longer PFS and OS than those in the cachexia or PS1‐3 group. CONCLUSIONS: In NSCLC patients, cachexia was associated with a worse prognosis, irrespective of tumor PD‐L1 expression, indicating that cachexia is a predictive factor for NSCLC patients receiving immune checkpoint inhibitors. John Wiley & Sons Australia, Ltd 2023-04-10 /pmc/articles/PMC10212657/ /pubmed/37037511 http://dx.doi.org/10.1111/1759-7714.14881 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Matsuo, Norikazu Azuma, Koichi Murotani, Kenta Murata, Daiki Matama, Goushi Kawahara, Akihiko Kojima, Takashi Tokito, Takaaki Hoshino, Tomoaki Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title | Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title_full | Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title_fullStr | Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title_full_unstemmed | Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title_short | Prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
title_sort | prognostic effect of cachexia in patients with non‐small cell lung cancer receiving immune checkpoint inhibitors |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212657/ https://www.ncbi.nlm.nih.gov/pubmed/37037511 http://dx.doi.org/10.1111/1759-7714.14881 |
work_keys_str_mv | AT matsuonorikazu prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT azumakoichi prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT murotanikenta prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT muratadaiki prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT matamagoushi prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT kawaharaakihiko prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT kojimatakashi prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT tokitotakaaki prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors AT hoshinotomoaki prognosticeffectofcachexiainpatientswithnonsmallcelllungcancerreceivingimmunecheckpointinhibitors |