A case of development of autoimmune pulmonary alveolar proteinosis during the treatment of hypersensitivity pneumonitis

Herein, we report the case of a 73-year-old woman with an occupational history of plaster grinding who developed autoimmune pulmonary alveolar proteinosis (PAP) during the treatment of fibrotic hypersensitivity pneumonitis with steroids and immunosuppressive drugs. Based on the changes in computed t...

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Detalles Bibliográficos
Autores principales: Asami-Noyama, Maki, Ito, Kosuke, Harada, Misa, Hisamoto, Yukari, Kunihiro, Yoshie, Ikeda, Eiji, Yamamoto, Tasuku, Suizu, Junki, Fukatsu, Ayumi, Ohata, Syuichiro, Murata, Yoriyuki, Oishi, Keiji, Yamaji, Yoshikazu, Edakuni, Nobutaka, Kakugawa, Tomoyuki, Hirano, Tsunahiko, Matsunaga, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212751/
https://www.ncbi.nlm.nih.gov/pubmed/37251358
http://dx.doi.org/10.1016/j.rmcr.2023.101862
Descripción
Sumario:Herein, we report the case of a 73-year-old woman with an occupational history of plaster grinding who developed autoimmune pulmonary alveolar proteinosis (PAP) during the treatment of fibrotic hypersensitivity pneumonitis with steroids and immunosuppressive drugs. Based on the changes in computed tomography imaging findings, poor response to steroid therapy, and markedly elevated KL-6 levels, PAP was suspected and diagnosed by bronchoscopy. Repeated segmental bronchoalveolar lavage under high-flow nasal cannula oxygen therapy resulted in slight improvement. Steroids and immunosuppressive treatments for other interstitial lung diseases may cause PAP or exacerbate latent PAP.

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