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Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function

AIMS: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin sensitivity after bariatric (metabolic) surgery affect the human growth hormone system is yet uncle...

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Autores principales: Gancheva, Sofiya, Kahl, Sabine, Herder, Christian, Strassburger, Klaus, Sarabhai, Theresia, Pafili, Kalliopi, Szendroedi, Julia, Schlensak, Matthias, Roden, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212759/
https://www.ncbi.nlm.nih.gov/pubmed/36959287
http://dx.doi.org/10.1038/s41366-023-01292-7
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author Gancheva, Sofiya
Kahl, Sabine
Herder, Christian
Strassburger, Klaus
Sarabhai, Theresia
Pafili, Kalliopi
Szendroedi, Julia
Schlensak, Matthias
Roden, Michael
author_facet Gancheva, Sofiya
Kahl, Sabine
Herder, Christian
Strassburger, Klaus
Sarabhai, Theresia
Pafili, Kalliopi
Szendroedi, Julia
Schlensak, Matthias
Roden, Michael
author_sort Gancheva, Sofiya
collection PubMed
description AIMS: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin sensitivity after bariatric (metabolic) surgery affect the human growth hormone system is yet unclear. PARTICIPANTS AND METHODS: People with obesity (OBE, n = 79, BMI 50.8 ± 6.3 kg/m(2)) were studied before, 2, 12, 24 and 52 weeks after metabolic surgery and compared to lean healthy humans (control; CON, n = 24, BMI 24.3 ± 3.1 kg/m(2)). Tissue-specific insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps with D-[6,6-(2)H(2)]glucose. Fasting leptin, growth hormone (GH), insulin-like growth factor 1 (IGF-1) and IGF-binding proteins (IGFBP1, IGFBP3) were measured using ELISA. RESULTS: At baseline, OBE exhibited higher glycemia and leptinemia as well as pronounced peripheral, adipose tissue and hepatic insulin resistance compared to CON. GH and IGFBP1 were lower, while IGF1 was comparable between groups. At 52 weeks, OBE had lost 33% body weight and doubled their peripheral insulin sensitivity, which was paralleled by continuous increases in GH, IGF-1 and IGFBP1 as well as decrease in leptin. The rise in GH correlated with reductions in free fatty acids, adipose tissue insulin resistance and insulinemia, but not with changes in body weight, peripheral insulin sensitivity, glycemia or leptinemia. The rise in IGF-1 correlated with reduction in high-sensitive C-reactive protein. CONCLUSION: Reversal of alterations of the GH-IGF-1 axis after surgically-induced weight loss is unlikely related to improved leptin secretion and/or insulin sensitivity, but is rather associated with restored adipose tissue function and reduced low-grade inflammation.
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spelling pubmed-102127592023-05-27 Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function Gancheva, Sofiya Kahl, Sabine Herder, Christian Strassburger, Klaus Sarabhai, Theresia Pafili, Kalliopi Szendroedi, Julia Schlensak, Matthias Roden, Michael Int J Obes (Lond) Article AIMS: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin sensitivity after bariatric (metabolic) surgery affect the human growth hormone system is yet unclear. PARTICIPANTS AND METHODS: People with obesity (OBE, n = 79, BMI 50.8 ± 6.3 kg/m(2)) were studied before, 2, 12, 24 and 52 weeks after metabolic surgery and compared to lean healthy humans (control; CON, n = 24, BMI 24.3 ± 3.1 kg/m(2)). Tissue-specific insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps with D-[6,6-(2)H(2)]glucose. Fasting leptin, growth hormone (GH), insulin-like growth factor 1 (IGF-1) and IGF-binding proteins (IGFBP1, IGFBP3) were measured using ELISA. RESULTS: At baseline, OBE exhibited higher glycemia and leptinemia as well as pronounced peripheral, adipose tissue and hepatic insulin resistance compared to CON. GH and IGFBP1 were lower, while IGF1 was comparable between groups. At 52 weeks, OBE had lost 33% body weight and doubled their peripheral insulin sensitivity, which was paralleled by continuous increases in GH, IGF-1 and IGFBP1 as well as decrease in leptin. The rise in GH correlated with reductions in free fatty acids, adipose tissue insulin resistance and insulinemia, but not with changes in body weight, peripheral insulin sensitivity, glycemia or leptinemia. The rise in IGF-1 correlated with reduction in high-sensitive C-reactive protein. CONCLUSION: Reversal of alterations of the GH-IGF-1 axis after surgically-induced weight loss is unlikely related to improved leptin secretion and/or insulin sensitivity, but is rather associated with restored adipose tissue function and reduced low-grade inflammation. Nature Publishing Group UK 2023-03-23 2023 /pmc/articles/PMC10212759/ /pubmed/36959287 http://dx.doi.org/10.1038/s41366-023-01292-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gancheva, Sofiya
Kahl, Sabine
Herder, Christian
Strassburger, Klaus
Sarabhai, Theresia
Pafili, Kalliopi
Szendroedi, Julia
Schlensak, Matthias
Roden, Michael
Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title_full Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title_fullStr Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title_full_unstemmed Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title_short Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
title_sort metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212759/
https://www.ncbi.nlm.nih.gov/pubmed/36959287
http://dx.doi.org/10.1038/s41366-023-01292-7
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