The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms

N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(...

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Detalles Bibliográficos
Autores principales: Lv, Zhihua, Ran, Ruoxi, Yang, Yuting, Xiang, Meixian, Su, Hanwen, Huang, Jingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212880/
https://www.ncbi.nlm.nih.gov/pubmed/37227534
http://dx.doi.org/10.1007/s12672-023-00695-2
Descripción
Sumario:N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(6)A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m(6)A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease.

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