The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms

N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(...

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Autores principales: Lv, Zhihua, Ran, Ruoxi, Yang, Yuting, Xiang, Meixian, Su, Hanwen, Huang, Jingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212880/
https://www.ncbi.nlm.nih.gov/pubmed/37227534
http://dx.doi.org/10.1007/s12672-023-00695-2
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author Lv, Zhihua
Ran, Ruoxi
Yang, Yuting
Xiang, Meixian
Su, Hanwen
Huang, Jingtao
author_facet Lv, Zhihua
Ran, Ruoxi
Yang, Yuting
Xiang, Meixian
Su, Hanwen
Huang, Jingtao
author_sort Lv, Zhihua
collection PubMed
description N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(6)A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m(6)A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease.
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spelling pubmed-102128802023-05-27 The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms Lv, Zhihua Ran, Ruoxi Yang, Yuting Xiang, Meixian Su, Hanwen Huang, Jingtao Discov Oncol Review N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(6)A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m(6)A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease. Springer US 2023-05-25 /pmc/articles/PMC10212880/ /pubmed/37227534 http://dx.doi.org/10.1007/s12672-023-00695-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lv, Zhihua
Ran, Ruoxi
Yang, Yuting
Xiang, Meixian
Su, Hanwen
Huang, Jingtao
The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title_full The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title_fullStr The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title_full_unstemmed The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title_short The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
title_sort interplay between n6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212880/
https://www.ncbi.nlm.nih.gov/pubmed/37227534
http://dx.doi.org/10.1007/s12672-023-00695-2
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