Cargando…

CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer

Immune-checkpoint (IC) modulators like the poliovirus receptor (PVR) and programmed death ligand 1 (PD-L1) attenuate innate and adaptive immune responses and are potential therapeutic targets for diverse malignancies, including triple-negative breast cancer (TNBC). The retinoblastoma tumor suppresso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shrestha, Mariusz, Wang, Dong-Yu, Ben-David, Yaacov, Zacksenhaus, Eldad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213015/ https://www.ncbi.nlm.nih.gov/pubmed/37230983 http://dx.doi.org/10.1038/s41389-023-00475-1

Ejemplares similares

CDK4, pRB and E2F1: connected to insulin
por: Fajas, Lluis, et al.
Publicado: (2010)

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling
por: Wang, Dong-Yu, et al.
Publicado: (2019)

Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells
por: Ju, YoungJun, et al.
Publicado: (2021)

Molecular stratification within triple-negative breast cancer subtypes
por: Wang, Dong-Yu, et al.
Publicado: (2019)

Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes
por: Jiang, Zhe, et al.
Publicado: (2022)

Correlation of the TIGIT-PVR immune checkpoint axis with clinicopathological features in triple-negative breast cancer
por: Boissière-Michot, Florence, et al.
Publicado: (2022)

RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs
por: Robinson, Tyler J. W., et al.
Publicado: (2013)

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.
por: Maelandsmo, G. M., et al.
Publicado: (1996)

Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring
por: Nazari, Zahra, et al.
Publicado: (2017)

CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer
por: Stefansson, Olafur Andri, et al.
Publicado: (2011)

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
por: Costa, Clotilde, et al.
Publicado: (2016)

E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
por: Sahin, Fikret, et al.
Publicado: (2010)

Relevance of pRB Loss in Human Malignancies
por: Mandigo, Amy C., et al.
Publicado: (2022)

Stratifying the stratifiers of triple negative breast cancer
por: Wang, Dong-Yu, et al.
Publicado: (2020)

Correction: Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
por: Costa, Clotilde, et al.
Publicado: (2017)

Methylation data of mouse Rb-deficient pineoblastoma
por: Chung, Philip E.D., et al.
Publicado: (2020)

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma
por: Tsuda, H, et al.
Publicado: (2000)

Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells
por: Varma, Hemant, et al.
Publicado: (2007)

Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner
por: Kim, Su-Jung, et al.
Publicado: (2023)

Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4/CyclinD1‐pRB‐E2F1 pathway
por: Wang, Jing, et al.
Publicado: (2023)

PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer
por: Wu, Bin, et al.
Publicado: (2019)

A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis
por: Min, Xue, et al.
Publicado: (2021)

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma
por: Ewens, Kathryn G., et al.
Publicado: (2017)

Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
por: Uchida, Chiharu
Publicado: (2016)

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
por: Veas-Pérez de Tudela, Miguel, et al.
Publicado: (2015)

The vulnerability of RB loss in breast cancer: Targeting a void in cell cycle control
por: Knudsen, Erik S., et al.
Publicado: (2018)

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
por: Vietri, Michele, et al.
Publicado: (2006)

Inactivation of CDK/pRb Pathway Normalizes Survival Pattern of Lymphoblasts Expressing the FTLD-Progranulin Mutation c.709-1G>A
por: Alquezar, Carolina, et al.
Publicado: (2012)

Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift
por: Ciavarra, Giovanni, et al.
Publicado: (2010)

Critical Role of the Rb Family in Myoblast Survival and Fusion
por: Ciavarra, Giovanni, et al.
Publicado: (2011)

Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb
por: Mi, Da, et al.
Publicado: (2013)

pRb or its cousins: Who controls the family business?
por: Itahana, Koji, et al.
Publicado: (2012)

Timing is everything: Rb’s choice in islet-cell fate
por: Cai, Erica P, et al.
Publicado: (2014)

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
por: D’Oto, Alexandra, et al.
Publicado: (2021)

Dephosphorylation of Nucleophosmin by PP1β Facilitates pRB Binding and Consequent E2F1-dependent DNA Repair
por: Lin, Chiao Yun, et al.
Publicado: (2010)

Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma
por: Faruq, Omar, et al.
Publicado: (2022)

CENPF knockdown inhibits adriamycin chemoresistance in triple-negative breast cancer via the Rb-E2F1 axis
por: Wang, Depeng, et al.
Publicado: (2023)

WITHDRAWN: Elevated glucose promotes DNA replication and cancer cell growth through pRB-E2F1
Publicado: (2023)

pRb controls Estrogen Receptor alpha protein stability and activity
por: Caligiuri, Isabella, et al.
Publicado: (2013)

Antitumor mechanisms when pRb and p53 are genetically inactivated
por: Zhu, Liang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_292730e78vpepcdftlvfnlt3iv