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Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling

The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length, wild-type human p53 tetramer and their importance...

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Detalles Bibliográficos
Autores principales:	Di Ianni, Alessio, Tüting, Christian, Kipping, Marc, Ihling, Christian H., Köppen, Janett, Iacobucci, Claudio, Arlt, Christian, Kastritis, Panagiotis L., Sinz, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213020/ https://www.ncbi.nlm.nih.gov/pubmed/37231156 http://dx.doi.org/10.1038/s41598-023-35437-5

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