Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure. However its molecular structure has remained unkno...

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Detalles Bibliográficos
Autores principales: Liu, Qianying, Zhang, Xiang, Huang, Hui, Chen, Yuxin, Wang, Fang, Hao, Aihua, Zhan, Wuqiang, Mao, Qiyu, Hu, Yuxia, Han, Lin, Sun, Yifang, Zhang, Meng, Liu, Zhimin, Li, Geng-Lin, Zhang, Weijia, Shu, Yilai, Sun, Lei, Chen, Zhenguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213058/
https://www.ncbi.nlm.nih.gov/pubmed/37230976
http://dx.doi.org/10.1038/s41467-023-38303-0

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