PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice

BACKGROUND & AIMS: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage communication, and modulation of the gut microbiome...

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Detalles Bibliográficos
Autores principales: Canale, Vinicius, Spalinger, Marianne R., Alvarez, Rocio, Sayoc-Becerra, Anica, Sanati, Golshid, Manz, Salomon, Chatterjee, Pritha, Santos, Alina N., Lei, Hillmin, Jahng, Sharon, Chu, Timothy, Shawki, Ali, Hanson, Elaine, Eckmann, Lars, Ouellette, André J., McCole, Declan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213106/
https://www.ncbi.nlm.nih.gov/pubmed/37030630
http://dx.doi.org/10.1016/j.jcmgh.2023.03.009

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