Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors

The EphA2 receptor tyrosine kinase is overexpressed in most solid tumors and acts as the major driver of tumorigenesis. In this study, we developed a novel approach for targeting the EphA2 receptor using a 2′-fluoro-modified pyrimidine RNA aptamer termed ATOP. We identified the ATOP EphA2 aptamer us...

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Detalles Bibliográficos
Autores principales: Santana-Viera, Laura, Dassie, Justin P., Rosàs-Lapeña, Marta, Garcia-Monclús, Silvia, Chicón-Bosch, Mariona, Pérez-Capó, Marina, Pozo, Lidia del, Sanchez-Serra, Sara, Almacellas-Rabaiget, Olga, Maqueda-Marcos, Susana, López-Alemany, Roser, Thiel, William H., Giangrande, Paloma H., Tirado, Oscar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213179/
https://www.ncbi.nlm.nih.gov/pubmed/37251690
http://dx.doi.org/10.1016/j.omtn.2023.05.003

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