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Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice
The involvement of mitochondrial dysfunction in cystatin B (CSTB) deficiency has been suggested, but its role in the onset of neurodegeneration, myoclonus, and ataxia in the CSTB-deficient mouse model (Cstb(−/−)) is yet unknown. CSTB is an inhibitor of lysosomal and nuclear cysteine cathepsins. In h...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213208/ https://www.ncbi.nlm.nih.gov/pubmed/37251643 http://dx.doi.org/10.3389/fnmol.2023.1175851 |