Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue

Robust human immune system (HIS) mice are created using human fetal thymus tissue and hematopoietic stem cells (HSCs). A HIS mouse model using neonatal human thymus tissue and umbilical cord blood (CB) HSCs (NeoHu) was recently described. We improved the model by removing the native murine thymus, w...

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Detalles Bibliográficos
Autores principales: Talaie, Tara, Wang, Hui, Kuo, Wan-I, Danzl, Nichole, Gulsen, Mert R., Wolabaugh, Amber N., Ding, Xiaolan, Sykes, Megan, Li, Hao Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213218/
https://www.ncbi.nlm.nih.gov/pubmed/37251390
http://dx.doi.org/10.3389/fimmu.2023.1159341

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