Biomarkers of delirium risk in older adults: a systematic review and meta-analysis

Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two...

Descripción completa

Detalles Bibliográficos
Autores principales: Lozano-Vicario, Lucía, García-Hermoso, Antonio, Cedeno-Veloz, Bernardo Abel, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Romero-Ortuno, Román, Zambom-Ferraresi, Fabricio, Sáez de Asteasu, Mikel L., Muñoz-Vázquez, Ángel Javier, Izquierdo, Mikel, Martínez-Velilla, Nicolás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213257/
https://www.ncbi.nlm.nih.gov/pubmed/37251808
http://dx.doi.org/10.3389/fnagi.2023.1174644
Descripción
Sumario:Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-α, and IL-6 were the most consistent biomarkers of delirium in older patients.

Ejemplares similares