Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

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Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody responses elicited by prior vaccination and infection. The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated by the REGEN-COV therapeutic monoclonal antibod...

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Detalles Bibliográficos
Autores principales: Addetia, Amin, Park, Young-Jun, Starr, Tyler, Greaney, Allison J., Sprouse, Kaitlin R., Bowen, John E., Tiles, Sasha W., Van Voorhis, Wesley C., Bloom, Jesse D., Corti, Davide, Walls, Alexandra C., Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213294/
https://www.ncbi.nlm.nih.gov/pubmed/37300832
http://dx.doi.org/10.1016/j.celrep.2023.112621

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