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Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms

Obesity is a complex metabolic disease, with cognitive impairment being an essential complication. Gut microbiota differs markedly between individuals with and without obesity. The microbial–gut–brain axis is an important pathway through which metabolic factors, such as obesity, affect the brain. Pr...

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Autores principales: Cai, Yichen, Liu, Pan, Zhou, Xiaolan, Yuan, Jun, Chen, Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213414/
https://www.ncbi.nlm.nih.gov/pubmed/37249983
http://dx.doi.org/10.3389/fcimb.2023.1178399
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author Cai, Yichen
Liu, Pan
Zhou, Xiaolan
Yuan, Jun
Chen, Qiu
author_facet Cai, Yichen
Liu, Pan
Zhou, Xiaolan
Yuan, Jun
Chen, Qiu
author_sort Cai, Yichen
collection PubMed
description Obesity is a complex metabolic disease, with cognitive impairment being an essential complication. Gut microbiota differs markedly between individuals with and without obesity. The microbial–gut–brain axis is an important pathway through which metabolic factors, such as obesity, affect the brain. Probiotics have been shown to alleviate symptoms associated with obesity and neurobehavioral disorders. In this review, we evaluated previously published studies on the effectiveness of probiotic interventions in reducing cognitive impairment, depression, and anxiety associated with obesity or a high-fat diet. Most of the probiotics studied have beneficial health effects on obesity-induced cognitive impairment and anxiety. They positively affect immune regulation, the hypothalamic–pituitary–adrenal axis, hippocampal function, intestinal mucosa protection, and glucolipid metabolism regulation. Probiotics can influence changes in the composition of the gut microbiota and the ratio between various flora. However, probiotics should be used with caution, particularly in healthy individuals. Future research should further explore the mechanisms underlying the gut–brain axis, obesity, and cognitive function while overcoming the significant variation in study design and high risk of bias in the current evidence.
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spelling pubmed-102134142023-05-27 Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms Cai, Yichen Liu, Pan Zhou, Xiaolan Yuan, Jun Chen, Qiu Front Cell Infect Microbiol Cellular and Infection Microbiology Obesity is a complex metabolic disease, with cognitive impairment being an essential complication. Gut microbiota differs markedly between individuals with and without obesity. The microbial–gut–brain axis is an important pathway through which metabolic factors, such as obesity, affect the brain. Probiotics have been shown to alleviate symptoms associated with obesity and neurobehavioral disorders. In this review, we evaluated previously published studies on the effectiveness of probiotic interventions in reducing cognitive impairment, depression, and anxiety associated with obesity or a high-fat diet. Most of the probiotics studied have beneficial health effects on obesity-induced cognitive impairment and anxiety. They positively affect immune regulation, the hypothalamic–pituitary–adrenal axis, hippocampal function, intestinal mucosa protection, and glucolipid metabolism regulation. Probiotics can influence changes in the composition of the gut microbiota and the ratio between various flora. However, probiotics should be used with caution, particularly in healthy individuals. Future research should further explore the mechanisms underlying the gut–brain axis, obesity, and cognitive function while overcoming the significant variation in study design and high risk of bias in the current evidence. Frontiers Media S.A. 2023-05-12 /pmc/articles/PMC10213414/ /pubmed/37249983 http://dx.doi.org/10.3389/fcimb.2023.1178399 Text en Copyright © 2023 Cai, Liu, Zhou, Yuan and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Cai, Yichen
Liu, Pan
Zhou, Xiaolan
Yuan, Jun
Chen, Qiu
Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title_full Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title_fullStr Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title_full_unstemmed Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title_short Probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
title_sort probiotics therapy show significant improvement in obesity and neurobehavioral disorders symptoms
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213414/
https://www.ncbi.nlm.nih.gov/pubmed/37249983
http://dx.doi.org/10.3389/fcimb.2023.1178399
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