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Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP

N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typically elicited at normal pH values in healthy tissues...

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Detalles Bibliográficos
Autores principales:	Celik, Melih Özgür, Seitz, Viola, Yergöz, Fatih, Dembla, Sandeep, Blum, Nina Kathleen, Schulz, Stefan, Stein, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213447/ https://www.ncbi.nlm.nih.gov/pubmed/37251645 http://dx.doi.org/10.3389/fnmol.2023.1171855

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