Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe and efficacious payload delivery. Herein, we adapt drug-co...

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Detalles Bibliográficos
Autores principales: Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Pelin, Adrian, Boulton, Stephen, Petryk, Julia, Onsu, Kemal Alper, Martin, Nikolas T., Hoskin, Victoria, Ghahremani, Mina, Marotel, Marie, Marius, Ricardo, He, Xiaohong, Crupi, Mathieu J. F., Hoang, Huy-Dung, Nik-Akhtar, Abolfazl, Ahmadi, Mahsa, Zamani, Nika Kooshki, Golshani, Ashkan, Alain, Tommy, Greer, Peter, Ardolino, Michele, Dickinson, Bryan C., Tai, Lee-Hwa, Ilkow, Carolina S., Bell, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213590/
https://www.ncbi.nlm.nih.gov/pubmed/37236967
http://dx.doi.org/10.1038/s41467-023-38651-x

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