Serum albumin binding knob domains engineered within a V(H) framework III bispecific antibody format and as chimeric peptides

BACKGROUND: Serum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are the smallest single chain antibody fragments described to date and versatile tools for pr...

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Detalles Bibliográficos
Autores principales: Adams, Ralph, Joyce, Callum, Kuravskiy, Mikhail, Harrison, Katriona, Ahdash, Zainab, Balmforth, Matthew, Chia, Kelda, Marceddu, Cinzia, Coates, Matthew, Snowden, James, Goursaud, Emmanuel, Ménochet, Karelle, van den Elsen, Jean, Payne, Richard J., Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213618/
https://www.ncbi.nlm.nih.gov/pubmed/37251411
http://dx.doi.org/10.3389/fimmu.2023.1170357

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