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Update on transfusion-related acute lung injury: an overview of its pathogenesis and management

Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause of transfusion-associated death. Its poor associated prognosis is due, in large part, to the current dearth of effective therapeutic strategies. Hence, an urgent need exists for effective management strategie...

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Detalles Bibliográficos
Autores principales: Yu, Yunhong, Lian, Zhengqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213666/
https://www.ncbi.nlm.nih.gov/pubmed/37251400
http://dx.doi.org/10.3389/fimmu.2023.1175387
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author Yu, Yunhong
Lian, Zhengqiu
author_facet Yu, Yunhong
Lian, Zhengqiu
author_sort Yu, Yunhong
collection PubMed
description Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause of transfusion-associated death. Its poor associated prognosis is due, in large part, to the current dearth of effective therapeutic strategies. Hence, an urgent need exists for effective management strategies for the prevention and treatment of associated lung edema. Recently, various preclinical and clinical studies have advanced the current knowledge regarding TRALI pathogenesis. In fact, the application of this knowledge to patient management has successfully decreased TRALI-associated morbidity. This article reviews the most relevant data and recent progress related to TRALI pathogenesis. Based on the existing two-hit theory, a novel three-step pathogenesis model composed of a priming step, pulmonary reaction, and effector phase is postulated to explain the process of TRALI. TRALI pathogenesis stage-specific management strategies based on clinical studies and preclinical models are summarized with an explication of their models of prevention and experimental drugs. The primary aim of this review is to provide useful insights regarding the underlying pathogenesis of TRALI to inform the development of preventive or therapeutic alternatives.
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spelling pubmed-102136662023-05-27 Update on transfusion-related acute lung injury: an overview of its pathogenesis and management Yu, Yunhong Lian, Zhengqiu Front Immunol Immunology Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause of transfusion-associated death. Its poor associated prognosis is due, in large part, to the current dearth of effective therapeutic strategies. Hence, an urgent need exists for effective management strategies for the prevention and treatment of associated lung edema. Recently, various preclinical and clinical studies have advanced the current knowledge regarding TRALI pathogenesis. In fact, the application of this knowledge to patient management has successfully decreased TRALI-associated morbidity. This article reviews the most relevant data and recent progress related to TRALI pathogenesis. Based on the existing two-hit theory, a novel three-step pathogenesis model composed of a priming step, pulmonary reaction, and effector phase is postulated to explain the process of TRALI. TRALI pathogenesis stage-specific management strategies based on clinical studies and preclinical models are summarized with an explication of their models of prevention and experimental drugs. The primary aim of this review is to provide useful insights regarding the underlying pathogenesis of TRALI to inform the development of preventive or therapeutic alternatives. Frontiers Media S.A. 2023-05-12 /pmc/articles/PMC10213666/ /pubmed/37251400 http://dx.doi.org/10.3389/fimmu.2023.1175387 Text en Copyright © 2023 Yu and Lian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yu, Yunhong
Lian, Zhengqiu
Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title_full Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title_fullStr Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title_full_unstemmed Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title_short Update on transfusion-related acute lung injury: an overview of its pathogenesis and management
title_sort update on transfusion-related acute lung injury: an overview of its pathogenesis and management
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213666/
https://www.ncbi.nlm.nih.gov/pubmed/37251400
http://dx.doi.org/10.3389/fimmu.2023.1175387
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