Cargando…

Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner

Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia, gestational diabetes is associated with abnormal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nashif, Sereen K., Mahr, Renee M., Jena, Snehalata, Jo, Seokwon, Nelson, Alisa B., Sadowski, Danielle, Crawford, Peter A., Puchalska, Patrycja, Alejandro, Emilyn U., Gearhart, Micah D., Wernimont, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213689/ https://www.ncbi.nlm.nih.gov/pubmed/37250894 http://dx.doi.org/10.3389/fcell.2023.1167097

Ejemplares similares

Mitochondrial citrate metabolism and efflux regulate BeWo differentiation
por: Mahr, Renee M., et al.
Publicado: (2023)

Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines
por: Nelson, Alisa B., et al.
Publicado: (2022)

RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development
por: Jo, Seokwon, et al.
Publicado: (2023)

The trophoblast giant cells of cricetid rodents
por: Favaron, Phelipe O., et al.
Publicado: (2023)

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta
por: Marsh, Bryan, et al.
Publicado: (2022)

Gender-based heterogeneity of FAHFAs in trained runners
por: Nelson, Alisa B., et al.
Publicado: (2023)

RNA Network Interactions During Differentiation of Human Trophoblasts
por: Chu, Tianjiao, et al.
Publicado: (2021)

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice
por: Stagg, David B., et al.
Publicado: (2021)

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development
por: Sung, Derek C, et al.
Publicado: (2022)

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast
por: Morey, Robert, et al.
Publicado: (2021)

Transcriptional regulation of Satb1 in mouse trophoblast stem cells
por: Yu, Wei, et al.
Publicado: (2022)

Exploring maternal-fetal interface with in vitro placental and trophoblastic models
por: Liu, Xinlu, et al.
Publicado: (2023)

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells
por: Esch, Nicholas, et al.
Publicado: (2020)

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion
por: Perez-Garcia, Vicente, et al.
Publicado: (2021)

The metabolic response of human trophoblasts derived from term placentas to metformin
por: Tarry-Adkins, Jane L., et al.
Publicado: (2023)

Laminins Regulate Placentation and Pre-eclampsia: Focus on Trophoblasts and Endothelial Cells
por: Liu, Min, et al.
Publicado: (2020)

The BMP2 Signaling Axis Promotes Invasive Differentiation of Human Trophoblasts
por: You, Jiali, et al.
Publicado: (2021)

Prednisolone Alters Endometrial Decidual Cells and Affects Decidual-Trophoblast Interactions
por: Grbac, Eliza, et al.
Publicado: (2021)

Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters
por: Karahoda, Rona, et al.
Publicado: (2022)

TAGLN2-Regulated Trophoblast Migration, Invasion and Fusion are Impaired in Preeclampsia
por: Wang, Hao, et al.
Publicado: (2022)

Corrigendum: Transcriptomic drivers of differentiation, maturation, and polyploidy in human extravillous trophoblast
por: Morey, Robert, et al.
Publicado: (2023)

Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS
por: Lacin, Haluk, et al.
Publicado: (2019)

LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells
por: Wang, Yiming, et al.
Publicado: (2022)

Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion
por: Ozmen, Asli, et al.
Publicado: (2022)

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia
por: Hayder, Heyam, et al.
Publicado: (2022)

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring
por: Moore, Mackenzie, et al.
Publicado: (2021)

Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams
por: Chung, Grace, et al.
Publicado: (2022)

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
por: Corbel, Catherine, et al.
Publicado: (2016)

The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner
por: Germani, Federico, et al.
Publicado: (2018)

Upregulation of RND3 Affects Trophoblast Proliferation, Apoptosis, and Migration at the Maternal-Fetal Interface
por: Ma, Xiao-Ling, et al.
Publicado: (2020)

Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome
por: Rosario, Fredrick J., et al.
Publicado: (2021)

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast
por: Wang, He, et al.
Publicado: (2021)

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis
por: Lv, Zi, et al.
Publicado: (2021)

Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis
por: Agrimson, Kellie S., et al.
Publicado: (2022)

Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice
por: López-Tello, Jorge, et al.
Publicado: (2019)

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin
por: Wang, Miaomiao, et al.
Publicado: (2021)

The chemokine receptor CXCR4 regulates satellite cell activation, early expansion, and self-renewal, in response to skeletal muscle injury
por: Shams, Ahmed S., et al.
Publicado: (2022)

Knockdown of Splicing Complex Protein PCBP2 Reduces Extravillous Trophoblast Differentiation Through Transcript Switching
por: Georgiadou, Danai, et al.
Publicado: (2021)

Advanced Oxidative Protein Products Drive Trophoblast Cells Into Senescence by Inhibiting the Autophagy: The Potential Implication of Preeclampsia
por: Li, Zhengjuan, et al.
Publicado: (2022)

The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing
por: Ma, Jingmei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4n4f6rvk3dcv9k43gjo24qn0jd