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Biomarkers detected in cord blood predict vaccine responses in young infants
INTRODUCTION: Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival b...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213698/ https://www.ncbi.nlm.nih.gov/pubmed/37251388 http://dx.doi.org/10.3389/fimmu.2023.1152538 |
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author | Baloh, Carolyn H. Venturi, Guglielmo M. Fischer, Bernard M. Sadder, Liane S. Kim-Chang, Julie J. Chan, Cliburn De Paris, Kristina Yin, Li Aldrovandi, Grace M. Goodenow, Maureen M. Sleasman, John W. |
author_facet | Baloh, Carolyn H. Venturi, Guglielmo M. Fischer, Bernard M. Sadder, Liane S. Kim-Chang, Julie J. Chan, Cliburn De Paris, Kristina Yin, Li Aldrovandi, Grace M. Goodenow, Maureen M. Sleasman, John W. |
author_sort | Baloh, Carolyn H. |
collection | PubMed |
description | INTRODUCTION: Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year. METHODS: Longitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Bordetella pertussis, tetanus toxoid, and conjugated Haemophilus influenzae type B (HiB) were outcome measures. RESULTS: Using a least absolute shrinkage and selection operator (lasso) regression model, cord blood (CB) plasma IL-2, IL-17A, IL-31, and soluble CD14 (sCD14) were positively associated with pertussis IgG levels at 12 months, while CB plasma concentrations of APRIL and IL-33 were negatively associated. In contrast, CB concentrations of sCD14 and APRIL were positively associated with sustained tetanus IgG levels. A separate cross-sectional analysis of 18 mother/newborn pairs indicated that CB biomarkers were not due to transplacental transfer, but rather due to immune activation at the fetal/maternal interface. Elevated percentages of cord blood switched memory B cells were positively associated with 12-month HiB IgG levels. BAFF concentrations at 6 and 12 months were positively associated with pertussis and HiB IgG levels respectively. DISCUSSION: Sustained B cell immunity is highly influenced by early life immune dynamics beginning prior to birth. The findings provide important insights into how germinal center development shapes vaccine responses in healthy infants and provide a foundation for studies of conditions that impair infant immune development. |
format | Online Article Text |
id | pubmed-10213698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102136982023-05-27 Biomarkers detected in cord blood predict vaccine responses in young infants Baloh, Carolyn H. Venturi, Guglielmo M. Fischer, Bernard M. Sadder, Liane S. Kim-Chang, Julie J. Chan, Cliburn De Paris, Kristina Yin, Li Aldrovandi, Grace M. Goodenow, Maureen M. Sleasman, John W. Front Immunol Immunology INTRODUCTION: Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year. METHODS: Longitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Bordetella pertussis, tetanus toxoid, and conjugated Haemophilus influenzae type B (HiB) were outcome measures. RESULTS: Using a least absolute shrinkage and selection operator (lasso) regression model, cord blood (CB) plasma IL-2, IL-17A, IL-31, and soluble CD14 (sCD14) were positively associated with pertussis IgG levels at 12 months, while CB plasma concentrations of APRIL and IL-33 were negatively associated. In contrast, CB concentrations of sCD14 and APRIL were positively associated with sustained tetanus IgG levels. A separate cross-sectional analysis of 18 mother/newborn pairs indicated that CB biomarkers were not due to transplacental transfer, but rather due to immune activation at the fetal/maternal interface. Elevated percentages of cord blood switched memory B cells were positively associated with 12-month HiB IgG levels. BAFF concentrations at 6 and 12 months were positively associated with pertussis and HiB IgG levels respectively. DISCUSSION: Sustained B cell immunity is highly influenced by early life immune dynamics beginning prior to birth. The findings provide important insights into how germinal center development shapes vaccine responses in healthy infants and provide a foundation for studies of conditions that impair infant immune development. Frontiers Media S.A. 2023-05-12 /pmc/articles/PMC10213698/ /pubmed/37251388 http://dx.doi.org/10.3389/fimmu.2023.1152538 Text en Copyright © 2023 Baloh, Venturi, Fischer, Sadder, Kim-Chang, Chan, De Paris, Yin, Aldrovandi, Goodenow and Sleasman https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Baloh, Carolyn H. Venturi, Guglielmo M. Fischer, Bernard M. Sadder, Liane S. Kim-Chang, Julie J. Chan, Cliburn De Paris, Kristina Yin, Li Aldrovandi, Grace M. Goodenow, Maureen M. Sleasman, John W. Biomarkers detected in cord blood predict vaccine responses in young infants |
title | Biomarkers detected in cord blood predict vaccine responses in young infants |
title_full | Biomarkers detected in cord blood predict vaccine responses in young infants |
title_fullStr | Biomarkers detected in cord blood predict vaccine responses in young infants |
title_full_unstemmed | Biomarkers detected in cord blood predict vaccine responses in young infants |
title_short | Biomarkers detected in cord blood predict vaccine responses in young infants |
title_sort | biomarkers detected in cord blood predict vaccine responses in young infants |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213698/ https://www.ncbi.nlm.nih.gov/pubmed/37251388 http://dx.doi.org/10.3389/fimmu.2023.1152538 |
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