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The use of Trojan-horse drug delivery system in managing periodontitis

The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted usin...

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Autores principales: Géczi, Zoltán, Róth, Ivett, Kőhidai, Zsófia, Kőhidai, László, Mukaddam, Khaled, Hermann, Péter, Végh, Dániel, Zelles, Tivadar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213762/
https://www.ncbi.nlm.nih.gov/pubmed/36175203
http://dx.doi.org/10.1016/j.identj.2022.08.003
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author Géczi, Zoltán
Róth, Ivett
Kőhidai, Zsófia
Kőhidai, László
Mukaddam, Khaled
Hermann, Péter
Végh, Dániel
Zelles, Tivadar
author_facet Géczi, Zoltán
Róth, Ivett
Kőhidai, Zsófia
Kőhidai, László
Mukaddam, Khaled
Hermann, Péter
Végh, Dániel
Zelles, Tivadar
author_sort Géczi, Zoltán
collection PubMed
description The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted using MEDLINE, Embase, Web of Science Core Collection, and Google Scholar search engines. We also reviewed several reference lists of the included studies or relevant reviews identified by the search. By using Medical Subject Headings (MeSH) terminology, a comprehensive search was performed for the following keywords: silver, folic acid, periodontitis, macrophages, Trojan-horse mechanism, toxicity, and targeting. Using the keywords mentioned earlier, we selected 110 articles and after appropriate elimination the review was written based on 37 papers. Accordingly the we noted that silver isons were an effective approach to kill oral pathogens. Secondly the Trojan-horse mechanism. could be used by macrophages (as the Trojan horse) to deliver silver ions in large quantities to the inflammatory focus to kill the periodontopathogens. The Trojan-horse mechanism has never been described in the field of dentistry before. The proposed novel approach using the principle of Trojan Horse delivery of drugs/chemicals could be used to manage oral inflammatory conditions. This method can be used to supplement regular treatments.
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spelling pubmed-102137622023-05-27 The use of Trojan-horse drug delivery system in managing periodontitis Géczi, Zoltán Róth, Ivett Kőhidai, Zsófia Kőhidai, László Mukaddam, Khaled Hermann, Péter Végh, Dániel Zelles, Tivadar Int Dent J Concise Review The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted using MEDLINE, Embase, Web of Science Core Collection, and Google Scholar search engines. We also reviewed several reference lists of the included studies or relevant reviews identified by the search. By using Medical Subject Headings (MeSH) terminology, a comprehensive search was performed for the following keywords: silver, folic acid, periodontitis, macrophages, Trojan-horse mechanism, toxicity, and targeting. Using the keywords mentioned earlier, we selected 110 articles and after appropriate elimination the review was written based on 37 papers. Accordingly the we noted that silver isons were an effective approach to kill oral pathogens. Secondly the Trojan-horse mechanism. could be used by macrophages (as the Trojan horse) to deliver silver ions in large quantities to the inflammatory focus to kill the periodontopathogens. The Trojan-horse mechanism has never been described in the field of dentistry before. The proposed novel approach using the principle of Trojan Horse delivery of drugs/chemicals could be used to manage oral inflammatory conditions. This method can be used to supplement regular treatments. Elsevier 2022-09-26 /pmc/articles/PMC10213762/ /pubmed/36175203 http://dx.doi.org/10.1016/j.identj.2022.08.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Concise Review
Géczi, Zoltán
Róth, Ivett
Kőhidai, Zsófia
Kőhidai, László
Mukaddam, Khaled
Hermann, Péter
Végh, Dániel
Zelles, Tivadar
The use of Trojan-horse drug delivery system in managing periodontitis
title The use of Trojan-horse drug delivery system in managing periodontitis
title_full The use of Trojan-horse drug delivery system in managing periodontitis
title_fullStr The use of Trojan-horse drug delivery system in managing periodontitis
title_full_unstemmed The use of Trojan-horse drug delivery system in managing periodontitis
title_short The use of Trojan-horse drug delivery system in managing periodontitis
title_sort use of trojan-horse drug delivery system in managing periodontitis
topic Concise Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213762/
https://www.ncbi.nlm.nih.gov/pubmed/36175203
http://dx.doi.org/10.1016/j.identj.2022.08.003
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