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The use of Trojan-horse drug delivery system in managing periodontitis
The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted usin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213762/ https://www.ncbi.nlm.nih.gov/pubmed/36175203 http://dx.doi.org/10.1016/j.identj.2022.08.003 |
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author | Géczi, Zoltán Róth, Ivett Kőhidai, Zsófia Kőhidai, László Mukaddam, Khaled Hermann, Péter Végh, Dániel Zelles, Tivadar |
author_facet | Géczi, Zoltán Róth, Ivett Kőhidai, Zsófia Kőhidai, László Mukaddam, Khaled Hermann, Péter Végh, Dániel Zelles, Tivadar |
author_sort | Géczi, Zoltán |
collection | PubMed |
description | The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted using MEDLINE, Embase, Web of Science Core Collection, and Google Scholar search engines. We also reviewed several reference lists of the included studies or relevant reviews identified by the search. By using Medical Subject Headings (MeSH) terminology, a comprehensive search was performed for the following keywords: silver, folic acid, periodontitis, macrophages, Trojan-horse mechanism, toxicity, and targeting. Using the keywords mentioned earlier, we selected 110 articles and after appropriate elimination the review was written based on 37 papers. Accordingly the we noted that silver isons were an effective approach to kill oral pathogens. Secondly the Trojan-horse mechanism. could be used by macrophages (as the Trojan horse) to deliver silver ions in large quantities to the inflammatory focus to kill the periodontopathogens. The Trojan-horse mechanism has never been described in the field of dentistry before. The proposed novel approach using the principle of Trojan Horse delivery of drugs/chemicals could be used to manage oral inflammatory conditions. This method can be used to supplement regular treatments. |
format | Online Article Text |
id | pubmed-10213762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102137622023-05-27 The use of Trojan-horse drug delivery system in managing periodontitis Géczi, Zoltán Róth, Ivett Kőhidai, Zsófia Kőhidai, László Mukaddam, Khaled Hermann, Péter Végh, Dániel Zelles, Tivadar Int Dent J Concise Review The aim of this review is to evaluate the possibility of delivering a silver-acid complex via a Trojan-horse mechanism for managing periodontits. We theroised that the complex could be an effective treatment option for bacterial inflammatory processes in the oral cavity. Searches were conducted using MEDLINE, Embase, Web of Science Core Collection, and Google Scholar search engines. We also reviewed several reference lists of the included studies or relevant reviews identified by the search. By using Medical Subject Headings (MeSH) terminology, a comprehensive search was performed for the following keywords: silver, folic acid, periodontitis, macrophages, Trojan-horse mechanism, toxicity, and targeting. Using the keywords mentioned earlier, we selected 110 articles and after appropriate elimination the review was written based on 37 papers. Accordingly the we noted that silver isons were an effective approach to kill oral pathogens. Secondly the Trojan-horse mechanism. could be used by macrophages (as the Trojan horse) to deliver silver ions in large quantities to the inflammatory focus to kill the periodontopathogens. The Trojan-horse mechanism has never been described in the field of dentistry before. The proposed novel approach using the principle of Trojan Horse delivery of drugs/chemicals could be used to manage oral inflammatory conditions. This method can be used to supplement regular treatments. Elsevier 2022-09-26 /pmc/articles/PMC10213762/ /pubmed/36175203 http://dx.doi.org/10.1016/j.identj.2022.08.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Concise Review Géczi, Zoltán Róth, Ivett Kőhidai, Zsófia Kőhidai, László Mukaddam, Khaled Hermann, Péter Végh, Dániel Zelles, Tivadar The use of Trojan-horse drug delivery system in managing periodontitis |
title | The use of Trojan-horse drug delivery system in managing periodontitis |
title_full | The use of Trojan-horse drug delivery system in managing periodontitis |
title_fullStr | The use of Trojan-horse drug delivery system in managing periodontitis |
title_full_unstemmed | The use of Trojan-horse drug delivery system in managing periodontitis |
title_short | The use of Trojan-horse drug delivery system in managing periodontitis |
title_sort | use of trojan-horse drug delivery system in managing periodontitis |
topic | Concise Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213762/ https://www.ncbi.nlm.nih.gov/pubmed/36175203 http://dx.doi.org/10.1016/j.identj.2022.08.003 |
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