Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects

Using chemoproteomic techniques, we first identified EIF2AK2, eEF1A1, PRDX3 and VPS4B as direct targets of berberine (BBR) for its synergistically anti-inflammatory effects. Of them, BBR has the strongest affinity with EIF2AK2 via two ionic bonds, and regulates several key inflammatory pathways thro...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Zeng, Qingxuan, Wang, Yan, Guo, Xixi, Fan, Tianyun, Li, Yinghong, Deng, Hongbin, Zhao, Liping, Zhang, Xintong, Liu, Yonghua, Shi, Yulong, Zhu, Jingyang, Ma, Xican, Wang, Yanxiang, Jiang, Jiandong, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213791/
https://www.ncbi.nlm.nih.gov/pubmed/37250154
http://dx.doi.org/10.1016/j.apsb.2022.12.009

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